Evidence map›Paper›PMID 34202791›Full record

ArticlePolymers2021

Design and Optimization of a Self-Assembling Complex Based on Microencapsulated Calcium Alginate and Glutathione (CAG) Using Response Surface Methodology.

Ricardo I Castro, Luis Morales-Quintana, Nancy Alvarado, Luis Guzmán, Oscar Forero-Doria, Felipe Valenzuela-Riffo, V Felipe Laurie

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Understanding Mechanical Properties ofMaterials (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ricardo I CastroMultidisciplinary Agroindustry Research Laboratory, Carrera de Ingeniería en Construcción, Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, 5 Poniente 1670, Talca 3460000, Chile.ORCID 0000-0002-8054-1469
Luis Morales-QuintanaMultidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, 5 Poniente 1670, Talca 3460000, Chile.ORCID 0000-0002-7194-1989
Nancy AlvaradoInstituto de Ciencias Químicas Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, Av. El Llano Subercaseaux 2801, San Miguel, Santiago 8910060, Chile.ORCID 0000-0001-9698-1621
Luis GuzmánDepartment of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile.
Oscar Forero-DoriaDepartamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomás, Talca 3460000, Chile.
Felipe Valenzuela-RiffoPrograma de Doctorado en Ciencias con Mención Ingeniería Genética Vegetal, Instituto de Ciencias Biológicas, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile.ORCID 0000-0001-7396-5207
V Felipe LaurieFacultad de Ciencias Agrarias, Universidad de Talca, 2 Norte 285, Talca 3460000, Chile.ORCID 0000-0003-4465-2337
Universidad Autónoma de Chile · CLUniversity of Talca · CLUniversidad Santo Tomás · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to characterize and optimize the formation of molecular complexes produced by the association of calcium alginate and reduced glutathione (GSH). The influence of varying concentrations of calcium and GSH on the production of microcapsules was analyzed using response surface methodology (RSM). The microcapsules were characterized by thermogravimetric analysis (TGA-DTG) and infrared spectroscopy (FTIR) in order to assess the hydration of the complexes, their thermal stability, and the presence of GSH within the complexes. The optimum conditions proposed by RSM to reach the maximum concentration of GSH within complexes were a 15%

Indexed as

alginateglutathionemicroencapsulated

Identifiers

PMID34202791
PMCPMC8271790
OpenAlexW3176111283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.