ReviewInternational journal of molecular sciences2021
Melatonin in Early Nutrition: Long-Term Effects on Cardiovascular System.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Melatonin and Lactation in Ruminants Dairy Animals: A Systematic Review and Meta-Analysis of Preclinical Studies.Health science reports · 2026Review
- Melatonin and circadian regulation of inflammatory-oxidative pathways in pediatric neurological disorders.BMC pediatrics · 2026Review
- Diurnal rhythms in melatonin and cortisol in very preterm human milk.Frontiers in nutrition · 2026Article
- Blood Melatonin in Breast Milk-Fed Preterm Infants: Longitudinal Biomonitoring to 38 Weeks' Postmenstrual Age (ProMote Study).Children (Basel, Switzerland) · 2025Article
- Breastfeeding: The Multifaceted Impact on Child Development and Maternal Well-Being.Nutrients · 2025Review
- Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication.Molecular and cellular biochemistry · 2025Review
- Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis.Stem cells international · 2025Review
- Article
- Day/night fluctuations of breast milk bioactive factors and microbiome.Frontiers in nutrition · 2025Article
- Feeding Expressed Breast Milk Alters the Microbial Network of Breast Milk and Increases Breast Milk Microbiome Diversity over Time.Microorganisms · 2024Article
- Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review).Children (Basel, Switzerland) · 2024Review
- Bioactive Components of Human Milk and Their Impact on Child's Health and Development, Literature Review.Nutrients · 2024Review
- Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?Nutrients · 2024Review
- Comprehensive review of melatonin as a promising nutritional and nutraceutical supplement.Heliyon · 2024Review
- Melatonin enhanced the cardioprotective effects of HTK solution on Langendorff-perfused mouse hearts subjected to ischemia/reperfusion.Iranian journal of basic medical sciences · 2024Article
- Melatonin as a Mediator of the Gut Microbiota-Host Interaction: Implications for Health and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report.Children (Basel, Switzerland) · 2023Article
- Role of Melatonin in Bovine Reproductive Biotechnology.Molecules (Basel, Switzerland) · 2023Review
- Melatonin Treatment in Kidney Diseases.Cells · 2023Review
- Designing artificial circadian environments with multisensory cares for supporting preterm infants' growth in NICUs.Frontiers in neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breastfeeding protects against adverse cardiovascular outcomes in the long term. Melatonin is an active molecule that is present in the breast milk produced at night beginning in the first stages of lactation. This indoleamine appears to be a relevant contributor to the benefits of breast milk because it can affect infant health in several ways. The melatonin concentration in breast milk varies in a circadian pattern, making breast milk a chrononutrient. The consumption of melatonin can induce the first circadian stimulation in the infant's body at an age when his/her own circadian machinery is not functioning yet. This molecule is also a powerful antioxidant with the ability to act on infant cells directly as a scavenger and indirectly by lowering oxidant molecule production and enhancing the antioxidant capacity of the body. Melatonin also participates in regulating inflammation. Furthermore, melatonin can participate in shaping the gut microbiota composition, richness, and variation over time, also modulating which molecules are absorbed by the host. In all these ways, melatonin from breast milk influences weight gain in infants, limiting the development of obesity and comorbidities in the long term, and it can help shape the ideal cellular environment for the development of the infant's cardiovascular system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.