Evidence map›Paper›PMID 34202721›Full record

ArticleMolecules (Basel, Switzerland)2021

Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin.

Sheng-Chieh Wang, Ruei-Nian Li, Li-Ching Lin, Jen-Yang Tang, Jui-Hsin Su, Jyh-Horng Sheu, Hsueh-Wei Chang

Open access · goldAbstract readComparative Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Analysis of Cembrane-Type Diterpenoids from Cultured Soft CoralInternational journal of molecular sciences · 2025
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  5. Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sheng-Chieh WangDepartment of Biomedical Science and Environmental Biology, Ph.D. Program in Life Sciences, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ruei-Nian LiDepartment of Biomedical Science and Environmental Biology, Ph.D. Program in Life Sciences, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-2569-1314
Li-Ching LinChi-Mei Foundation Medical Center, Department of Radiation Oncology, Tainan 71004, Taiwan.
Jen-Yang TangSchool of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-5690-0708
Jui-Hsin SuNational Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
Jyh-Horng SheuDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Hsueh-Wei ChangDepartment of Biomedical Science and Environmental Biology, Ph.D. Program in Life Sciences, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-0068-2366
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWChung Hwa University of Medical Technology · TWNational Dong Hwa University · TW

Funding

Health and welfare surcharge of tobacco products, the Ministry of Health and Welfare, Taiwan MOHW 110-TDU-B-212-144016Kaohsiung Medical University Hospital KMUH109-9M56Kaohsiung Medical University Research Center KMU-TC108A0Ministry of Science and Technology, Taiwan MOST 108-2320-B-037-015-MY3National Sun Yat-sen University-KMU Joint Research Project #NSYSUKMU 109-I002National Sun Yat-sen University-KMU Joint Research Project #NSYSUKMU 110-P016
6 · The paper itself

Abstract

Marine natural products are abundant resources for antioxidants, but the antioxidant property of the soft corals-derived sinularin and dihydrosinularin were unknown. This study aimed to assess antioxidant potential and antiproliferation effects of above compounds on cancer cells, and to investigate the possible relationships between them. Results show that sinularin and dihydrosinularin promptly reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl (

Indexed as

Antineoplastic AgentsAntioxidantsDiterpenesHeterocyclic Compounds, 3-RingAnimalsAnthozoaCell Line, TumorHumansNeoplasmsAntineoplastic AgentsAntioxidantsdihydrosinularinDiterpenesHeterocyclic Compounds, 3-Ringsinularinantioxidantcytotoxicitydihydrosinularinmarine natural productssinularinsoft coral

Identifiers

PMID34202721
PMCPMC8270243
OpenAlexW3176075505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.