ArticleAntioxidants (Basel, Switzerland)2021
Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load.Current neuropharmacology · 2025Pooled it
- Geroprotective applications of oleuropein and hydroxytyrosol through the hallmarks of ageing.GeroScience · 2026Review
- Polyphenol-rich extra-virgin olive oil influences bioenergetics and may modulate NLRP3 inflammasome in PBMCs from children and adolescents with obesity.Scientific reports · 2026Article
- Effect of Long-Term Storage Temperature on the Quality of Extra-Virgin Olive Oil (Coratina cv.): A Multivariate Discriminant Approach.Antioxidants (Basel, Switzerland) · 2025Article
- Regulatory of Oleuropein on the In Vitro Maturation of Oocytes and the Development of Parthenogenetic Embryos in Sheep.Animals : an open access journal from MDPI · 2025Article
- Dietary Patterns and Hypothyroidism in U.S. Adult Population.Nutrients · 2024Article
- Study of the oxidative stability via Oxitest and Rancimat of phenolic-rich olive oils obtained by a sequential process of dehydration, expeller and supercritical COFrontiers in nutrition · 2024Article
- Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Metabolites · 2023Review
- Synthesis and Characterization of a Biopolymer Pectin/Ethanolic Extract from Olive Mill Wastewater: In Vitro Safety and Efficacy Tests on Skin Wound Healing.International journal of molecular sciences · 2023Article
- Review
- The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota.Antioxidants (Basel, Switzerland) · 2023Review
- Editorial: New insights and perspectives of polyphenols in nutrition.Frontiers in nutrition · 2023Article
- Olive juice dry extract containing hydroxytyrosol, as a nontoxic and safe substance: Results from pre-clinical studies and review of toxicological studies.Toxicology reports · 2023Article
- Overview of the Polyphenols in Salicornia: From Recovery to Health-Promoting Effect.Molecules (Basel, Switzerland) · 2022Review
- Design of Functional Powdered Beverages Containing Co-Microcapsules of Sacha InchiAntioxidants (Basel, Switzerland) · 2022Article
- The Tower of Babel of Pharma-Food Study on Extra Virgin Olive Oil Polyphenols.Foods (Basel, Switzerland) · 2022Article
- Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals.Antioxidants (Basel, Switzerland) · 2022Article
- Correlation between Chemical Characterization and Biological Activity: An Urgent Need for Human Studies Using Extra Virgin Olive Oil.Antioxidants (Basel, Switzerland) · 2022Review
- A Tara Gum/Olive Mill Wastewaters Phytochemicals Conjugate as a New Ingredient for the Formulation of an Antioxidant-Enriched Pudding.Foods (Basel, Switzerland) · 2022Article
- Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expression, along with a down-modulation of Il-1β and iNOS expression. From factorial analysis results, 9 polyphenols were tentatively established to play a synergistic role in modulating DCs inflammatory ability, thus reducing the risk of chronic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.