Evidence map›Paper›PMID 34202660›Full record

ReviewPharmaceutics2021

Nanoparticles as a Tool in Neuro-Oncology Theranostics.

Andrea L Klein, Grant Nugent, John Cavendish, Werner J Geldenhuys, Krishnan Sriram, Dale Porter, Ross Fladeland, Paul R Lockman, Jonathan H Sherman

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Recent Trends in Biomedical Applications of CuInternational journal of nanomedicine · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea L KleinThe George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.ORCID 0000-0003-4146-3493
Grant NugentWest Virginia University School of Medicine, Morgantown, WV 26505, USA.
John CavendishWest Virginia University School of Medicine, Morgantown, WV 26505, USA.
Werner J GeldenhuysDepartment of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Krishnan SriramNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.ORCID 0000-0001-7005-1872
Dale PorterNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.ORCID 0000-0002-8358-6793
Ross FladelandDepartment of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26506, USA.ORCID 0000-0002-9259-6213
Paul R LockmanDepartment of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506, USA.ORCID 0000-0002-6995-9944
Jonathan H ShermanDepartment of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid growth of nanotechnology and the development of novel nanomaterials with unique physicochemical characteristics provides potential for the utility of nanomaterials in theranostics, including neuroimaging, for identifying neurodegenerative changes or central nervous system malignancy. Here we present a systematic and thorough review of the current evidence pertaining to the imaging characteristics of various nanomaterials, their associated toxicity profiles, and mechanisms for enhancing tropism in an effort to demonstrate the utility of nanoparticles as an imaging tool in neuro-oncology. Particular attention is given to carbon-based and metal oxide nanoparticles and their theranostic utility in MRI, CT, photoacoustic imaging, PET imaging, fluorescent and NIR fluorescent imaging, and SPECT imaging.

Indexed as

imagingnanoparticlesneuro-oncologyneurosurgerytheranostic

Identifiers

PMID34202660
PMCPMC8309086

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.