Evidence map›Paper›PMID 34202631›Full record

ReviewInternational journal of molecular sciences2021

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications.

Safeera Khan, Andrew Dunphy, Mmesoma S Anike, Sarah Belperain, Kamal Patel, Norman H L Chiu, Zhenquan Jia

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Potential of Carbon Nanodots (CNDs) in Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Safeera KhanDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Andrew DunphyDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Mmesoma S AnikeDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Sarah BelperainDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Kamal PatelDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Norman H L ChiuDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Zhenquan JiaDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.ORCID 0000-0002-5187-1549

Funding

Novel Carbon Nanodots against Vascular InflammationR15HL129212 · NHLBI · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JIA, ZHENQUAN · 2016 to 2016
$455k
Novel carbon nanodots for modulation of OxLDL mediated inflammation and inhibition of atherosclerosisR15HL150664 · NHLBI · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JIA, ZHENQUAN · 2020 to 2020
$447k
NHLBI NIH HHS R15 HL129212NHLBI NIH HHS R15 HL150664Office of Research Infrastructure Programs, National Institutes of Health 1R15HL129212-01A1 and 1R15HL150664-01A1
6 · The paper itself

Abstract

Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

Indexed as

Theranostic NanomedicineAntioxidantsBiotechnologyCarbonChemical PhenomenaChemistry Techniques, SyntheticHumansMolecular StructureNanostructuresOxidative StressPhotochemical ProcessesReactive Oxygen SpeciesStructure-Activity RelationshipAntioxidantsCarbonReactive Oxygen Speciesbiomedicinecarbon nanodotsnanomaterialsROS scavenging mechanism

Identifiers

PMID34202631
PMCPMC8269108

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.