Evidence map›Paper›PMID 34202610›Full record

ArticleMaterials (Basel, Switzerland)2021

A New Water-Soluble Thermosensitive Star-Like Copolymer as a Promising Carrier of the Chemotherapeutic Drug Doxorubicin.

Mariia Chernykh, Dmytro Zavalny, Viktoriya Sokolova, Stanislav Ponomarenko, Svitlana Prylutska, Yuliia Kuziv, Vasyl Chumachenko, Andrii Marynin, Nataliya Kutsevol, Matthias Epple and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Cytotoxicity of Hybrid Noble Metal-Polymer Composites.BioMed research international · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Mariia ChernykhTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Dmytro ZavalnyTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Viktoriya SokolovaCenter for Nanointegration Duisburg-Essen (CeNIDE), Institute of Inorganic Chemistry, University of Duisburg-Essen, University Street, 5-7, 45117 Essen, Germany.
Stanislav PonomarenkoTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Svitlana PrylutskaDepartment of Physiology, Plant Biochemistry and Bioenergetics, National University of Life and Environmental Science of Ukraine, Heroiv Oborony Street, 15, 03041 Kyiv, Ukraine.
Yuliia KuzivTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.ORCID 0000-0001-8005-8197
Vasyl ChumachenkoTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Andrii MaryninNational University of Food Technologies of Ukraine, Volodymyrska Street, 01033 Kyiv, Ukraine.ORCID 0000-0001-6692-7472
Nataliya KutsevolTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Matthias EppleCenter for Nanointegration Duisburg-Essen (CeNIDE), Institute of Inorganic Chemistry, University of Duisburg-Essen, University Street, 5-7, 45117 Essen, Germany.ORCID 0000-0002-1641-7068
Uwe RitterInstitute of Chemistry and Biotechnology, Technical University of Ilmenau, Weimarer Street, 25, 98693 Ilmenau, Germany.ORCID 0000-0002-9315-4863
Jacek PiosikLaboratory of Biophysics, Intercollegiate Faculty of Biotechnology UG-MUG, University of Gdansk, Abrahama 58, 80-307 Gdańsk, Poland.ORCID 0000-0002-5671-1915
Yuriy PrylutskyyTaras Shevchenko National University of Kyiv, Volodymyrska Street, 64, 01601 Kyiv, Ukraine.
Taras Shevchenko National University of Kyiv · UAUniversity of Duisburg-Essen · DENational University of Food Technologies · UANational University of Life and Environmental Sciences of Ukraine · UATechnische Universität Ilmenau · DEUniversity of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new water-soluble thermosensitive star-like copolymer, dextran-graft-poly-N-iso-propilacrylamide (D-g-PNIPAM), was created and characterized by various techniques (size-exclusion chromatography, differential scanning calorimetry, Fourier-transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS) spectroscopy). The viability of cancer cell lines (human transformed cervix epithelial cells, HeLa) as a model for cancer cells was studied using MTT and Live/Dead assays after incubation with a D-g-PNIPAM copolymer as a carrier for the drug doxorubicin (Dox) as well as a D-g-PNIPAM + Dox mixture as a function of the concentration. FTIR spectroscopy clearly indicated the complex formation of Dox with the D-g-PNIPAM copolymer. The size distribution of particles in Hank's solution was determined by the DLS technique at different temperatures. The in vitro uptake of the studied D-g-PNIPAM + Dox nanoparticles into cancer cells was demonstrated by confocal laser scanning microscopy. It was found that D-g-PNIPAM + Dox nanoparticles in contrast to Dox alone showed higher toxicity toward cancer cells. All of the aforementioned facts indicate a possibility of further preclinical studies of the water-soluble D-g-PNIPAM particles' behavior in animal tumor models in vivo as promising carriers of anticancer agents.

Indexed as

cytotoxicitydoxorubicinHeLa cellsin vitro uptakethermosensitive star-like copolymer

Identifiers

PMID34202610
PMCPMC8269508
OpenAlexW3174981662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.