Evidence map›Paper›PMID 34202578›Full record

Trial reportNutrients2021

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial.

Shaun Sabico, Mushira A Enani, Eman Sheshah, Naji J Aljohani, Dara A Aldisi, Naif H Alotaibi, Naemah Alshingetti, Suliman Y Alomar, Abdullah M Alnaami, Osama E Amer and 2 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 12 pooled it
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 12 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shaun SabicoChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5248-2350
Mushira A EnaniInfectious Diseases Section, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
Eman SheshahDiabetes Care Center, King Salman Bin Abdulaziz Hospital, Riyadh 12769, Saudi Arabia.
Naji J AljohaniChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Dara A AldisiDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Naif H AlotaibiDepartment of Medicine, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia.
Naemah AlshingettiObstetrics and Gynaecology Department, King Salman Bin Abdulaziz Hospital, Riyadh 11564, Saudi Arabia.
Suliman Y AlomarDoping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-2864-1649
Abdullah M AlnaamiChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Osama E AmerChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-8657-0682
Syed D HussainChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Nasser M Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5472-1725
King Saud University · SAKing Abdulaziz Hospital · SAKing Fahd Medical City · SA

Funding

Deanship of Scientific Research, King Saud University NA
6 · The paper itself

Abstract

objectiveVitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. STUDY DESIGN AND

settingA total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (

resultsVitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted

conclusionA 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.

Indexed as

COVID-19 Drug TreatmentAdministration, OralAdultAgedBlood GlucoseCholecalciferolCOVID-19Dietary SupplementsFemaleHospitalizationHumansKaplan-Meier EstimateLipidsMaleMiddle AgedNutritional StatusBlood GlucoseCholecalciferolLipidsVitamin DVitaminsclinical trialCOVID-19saudivitamin Dvitamin D insufficiency

Identifiers

PMID34202578
PMCPMC8308273
OpenAlexW3176713326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.