Evidence map›Paper›PMID 34202550›Full record

ArticleInternational journal of molecular sciences2021

Intracellular Delivery of Doxorubicin by Iron Oxide-Based Nano-Constructs Increases Clonogenic Inactivation of Ionizing Radiation in HeLa Cells.

Roxana Cristina Popescu, Diana Iulia Savu, Miriam Bierbaum, Adriana Grbenicek, Frank Schneider, Hiltraud Hosser, Bogdan Ștefan Vasile, Ecaterina Andronescu, Frederik Wenz, Frank A Giordano and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Roxana Cristina PopescuDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Diana Iulia SavuDepartment of Life and Environmental Physics, "Horia Hulubei" National Institute for Physics and Nuclear Engineering, 077125 Magurele, Romania.ORCID 0000-0002-0145-5176
Miriam BierbaumDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Adriana GrbenicekDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Frank SchneiderDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Hiltraud HosserDepartment of Anatomy and Developmental Biology, Center for Biomedicine and Medical Technology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Bogdan Ștefan VasileDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2267-6453
Ecaterina AndronescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-2226-5849
Frederik WenzCEO, University Medical Center Freiburg, 79106 Freiburg, Germany.
Frank A GiordanoDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Carsten HerskindDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Marlon R VeldwijkDepartment of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Heidelberg University · DEUniversitatea Națională de Știință și Tehnologie Politehnica București · ROHoria Hulubei National Institute for R and D in Physics and Nuclear Engineering · ROUniversity Medical Center Freiburg · DE

Funding

Deutscher Akademischer Austauschdienst 57299291Ministry of Education and Research, Romania 543PED/2019Ministry of Education and Research, Romania 64PCCDI/2018Ministry of Education and Research, Romania PN 19060203Ministry of Foreign Affairs POSCCE-A2-O2.2.1-2013-1/Priority Axe 2, Project no 638/12.03.2014, ID 1970, SMIS-CSNR code 48652
6 · The paper itself

Abstract

In this study, we determined the potential of polyethylene glycol-encapsulated iron oxide nanoparticles (IONP

Indexed as

Drug CarriersFerric CompoundsMetal NanoparticlesAntibiotics, AntineoplasticDose-Response Relationship, RadiationDoxorubicinHeLa CellsHumansRadiation, IonizingRadiation ToleranceAntibiotics, AntineoplasticDoxorubicinDrug CarriersFerric Compoundsferric oxidedoxorubicindrug deliveryiron oxidenanoparticlespolyethylene glycolradiosensitization

Identifiers

PMID34202550
PMCPMC8267614
OpenAlexW3176750429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.