Evidence map›Paper›PMID 34202543›Full record

ReviewBiomolecules2021

Ligands of Adrenergic Receptors: A Structural Point of View.

Yiran Wu, Liting Zeng, Suwen Zhao

Abstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Trial
  2. Development of pH-Sensitive β‑Adrenergic Receptor Antagonists.ACS pharmacology & translational science · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Central βVeterinary research communications · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yiran WuiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Liting ZengiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Suwen ZhaoiHuman Institute, ShanghaiTech University, Shanghai 201210, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.

Indexed as

Adrenergic AgonistsAdrenergic AntagonistsAmino Acid SequenceAnimalsCrystallography, X-RayEpinephrineHumansLigandsNorepinephrineProtein BindingProtein ConformationProtein Structure, SecondaryProtein Structure, TertiaryReceptors, AdrenergicAdrenergic AgonistsAdrenergic AntagonistsEpinephrineLigandsNorepinephrineReceptors, Adrenergicactivation mechanismadrenergic receptoradrenoreceptorallosteric modulatoraminergic receptorGPCRreceptor–ligand interactionsselectivitystructure-based drug design

Identifiers

PMID34202543
PMCPMC8301793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.