Evidence map›Paper›PMID 34202484›Full record

ArticleNutrients2021

LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later.

Diana Betancor, Alicia Gomez-Lopez, Carlos Villalobos-Vilda, Emilio Nuñez-Borque, Sergio Fernández-Bravo, Manuel De Las Heras Gozalo, Carlos Pastor-Vargas, Vanesa Esteban, Javier Cuesta-Herranz

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. IgE-mediated lipid transfer protein allergy in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
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  7. Review
  8. Article
  9. Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana BetancorDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Alicia Gomez-LopezDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Carlos Villalobos-VildaDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Emilio Nuñez-BorqueDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Sergio Fernández-BravoDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Manuel De Las Heras GozaloDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.
Carlos Pastor-VargasRETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-4678-7967
Vanesa EstebanDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.ORCID 0000-0002-7500-6277
Javier Cuesta-HerranzDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain.

Funding

Instituto de Salud Carlos III RD16/0006/0013
6 · The paper itself

Abstract

introductionAllergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis.

methodsOne hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods.

resultsTen years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly

conclusionPatients sensitized to nsLTP developed allergic reactions to other plant foods, mainly

Indexed as

AdultAllergensAntigens, PlantCarrier ProteinsCross ReactionsDesensitization, ImmunologicFemaleFollow-Up StudiesFood HypersensitivityFruitHumansImmunoglobulin EMaleNutsPlant ProteinsRosaceaeAllergensAntigens, PlantCarrier ProteinsImmunoglobulin Elipid transfer proteins, plantPlant ProteinsISACnsLTPnutpeachplant-food allergyPru p 3Rosaceae fruit

Identifiers

PMID34202484
PMCPMC8308245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.