Evidence map›Paper›PMID 34202439›Full record

ReviewCancers2021

Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets.

Irene López-Oreja, Heribert Playa-Albinyana, Fabián Arenas, Mónica López-Guerra, Dolors Colomer

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Irene López-OrejaExperimental Therapies in Lymphoid Neoplasms, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0001-6756-1820
Heribert Playa-AlbinyanaExperimental Therapies in Lymphoid Neoplasms, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-3447-3848
Fabián ArenasExperimental Therapies in Lymphoid Neoplasms, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-4329-8834
Mónica López-GuerraExperimental Therapies in Lymphoid Neoplasms, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-5545-0178
Dolors ColomerExperimental Therapies in Lymphoid Neoplasms, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0001-7486-8484
Centro de Investigación Biomédica en Red de Cáncer · ESUniversitat Pompeu Fabra · ES

Funding

Centro de Investigación Biomédica en Cáncer CB16/12/00334Generalitat de Catalunya 2017 SGR 1009Ministerio de Economía, Industria y Competitividad, Gobierno de España RTI2018-094584-B-I00
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel alterations have been described. Some of them impact on the prognosis and evolution of patients. The approval of BTK inhibitors, PI3K inhibitors and Bcl-2 inhibitors has drastically changed the treatment of patients with CLL. The effect of these new targeted therapies has been widely analyzed in

Indexed as

chronic lymphocytic leukemiaMAPKNOTCH1SF3B1toll-like receptor (TLR)

Identifiers

PMID34202439
PMCPMC8269088
OpenAlexW3174280017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.