Evidence map›Paper›PMID 34202311›Full record

ArticleGenes2021

Skeletal Deformities in Osterix-Cre;Tgfbr2

Kara Corps, Monica Stanwick, Juliann Rectenwald, Andrew Kruggel, Sarah B Peters

Open access · goldAbstract readCase Reports
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Impaired Tertiary Dentin Secretion after Shallow Injury inInternational journal of molecular sciences · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Frontiers in cell and developmental biology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kara CorpsDepartment of Veterinary Bioscience, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Monica StanwickDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, OH 43210, USA.
Juliann RectenwaldDepartment of Veterinary Bioscience, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Andrew KruggelDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, OH 43210, USA.
Sarah B PetersDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, OH 43210, USA.
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Mechanisms regulating afferent innervation in the dental pulpR00DE027706 · NIDCR · OHIO STATE UNIVERSITY · PI PETERS, SARAH · 2020 to 2022
$806k
Mechanisms regulating afferent innervation in the dental pulpK99DE027706 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PETERS, SARAH · 2018 to 2019
$242k
NCI NIH HHS P30 CA16058NIDCR NIH HHS K99 DE027706NIDCR NIH HHS R00 DE027706
6 · The paper itself

Abstract

Transforming growth factor β (TGFβ) signaling plays an important role in skeletal development. We previously demonstrated that the loss of TGFβ receptor II (Tgfbr2) in Osterix-Cre-expressing mesenchyme results in defects in bones and teeth due to reduced proliferation and differentiation in pre-osteoblasts and pre-odontoblasts. These Osterix-Cre;Tgfbr2

Indexed as

AnimalsBone and BonesCell DifferentiationDisease Models, AnimalGene Expression Regulation, DevelopmentalHumansIntegrasesMesodermMiceOsteoblastsOsteogenesisReceptor, Transforming Growth Factor-beta Type IISignal TransductionSkeletonSp7 Transcription FactorCre recombinaseIntegrasesReceptor, Transforming Growth Factor-beta Type IISp7 protein, mouseSp7 Transcription FactorTgfbr2 protein, mousebone developmentconditional knockoutCre recombinasemouse modelsoff-target Creosteochondral dysplasiaOsterix-CrepostnatalTGFbeta

Identifiers

PMID34202311
PMCPMC8307487
OpenAlexW3173858873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.