Evidence map›Paper›PMID 34202310›Full record

ArticleViruses2021

Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR.

Leah D Brandt, Shuang Guo, Kevin W Joseph, Jana L Jacobs, Asma Naqvi, John M Coffin, Mary F Kearney, Elias K Halvas, Xiaolin Wu, Stephen H Hughes and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Proviruses in CD4Science translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Leah D BrandtDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2007-933X
Shuang GuoCancer Research Technology Program, Leidos Biomedical Research, Inc., 8560 Progress Drive, ATRF, Room C3004, Frederick, MD 21701, USA.ORCID 0000-0002-6837-7125
Kevin W JosephDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.
Jana L JacobsDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.
Asma NaqviDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.
John M CoffinDepartment of Molecular Biology and Microbiology, Tufts University, 145 Harrison Avenue, Jaharis 409, Boston, MA 02111, USA.
Mary F KearneyHIV-Dynamics and Replication Program, National Cancer Institute, 1050 Boyles Street, Building 535, Room 308, Frederick, MD 21702, USA.
Elias K HalvasDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.
Xiaolin WuCancer Research Technology Program, Leidos Biomedical Research, Inc., 8560 Progress Drive, ATRF, Room C3004, Frederick, MD 21701, USA.
Stephen H HughesHIV-Dynamics and Replication Program, National Cancer Institute, 1050 Boyles Street, Building 535, Room 308, Frederick, MD 21702, USA.
John W MellorsDepartment of Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall-818, Pittsburgh, PA 15261, USA.
University of Pittsburgh · USLeidos (United States) · USNational Cancer Institute · USTufts University · US

Funding

Combined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6M
Retrovirus Evolution and CancerR35CA200421 · NCI · TUFTS UNIVERSITY BOSTON · PI COFFIN, JOHN M · 2016 to 2022
$6.5M
Quantify the Fraction of Proviruses That Express HIV RNA to Better Understand Proviral Latency and Its ReversalZIABC011698 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEARNEY, MARY · 2016 to 2025
$5.1M
Understanding Immune Evasion by HIV-1 RepliclonesR01AI165031 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HALVAS, ELIAS K. · 2021 to 2025
$3.6M
National Institute of Allergy and Infectious Diseases UM1AI126603 and UM1AI106701NCI NIH HHS HHSN261200800001E and 75N91019D00024NCI NIH HHS R35 CA200421NIAID NIH HHS R01 AI165031
6 · The paper itself

Abstract

Efforts to cure HIV-1 infection require better quantification of the HIV-1 reservoir, particularly the clones of cells harboring replication-competent (intact) proviruses, termed

Indexed as

Real-Time Polymerase Chain ReactionVirus Integration5'-NucleotidaseCD4-Positive T-LymphocytesCell LineGlycoproteinsHIV-1HIV InfectionsHumansLeukocytes, MononuclearProvirusesViral Load5'-NucleotidaseGlycoproteinsNT5C3A protein, humanHIV-1-infected cell clonesHIV-1 reservoirproviral integration sitesrepliclones

Identifiers

PMID34202310
PMCPMC8310066
OpenAlexW3175567978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.