Evidence map›Paper›PMID 34202301›Full record

ArticleLife (Basel, Switzerland)2021

Alantolactone Suppresses Proliferation and the Inflammatory Response in Human HaCaT Keratinocytes and Ameliorates Imiquimod-Induced Skin Lesions in a Psoriasis-Like Mouse Model.

Wen-Ho Chuo, Yu-Tang Tung, Chao-Liang Wu, Nicole R Bracci, Yu-Kang Chang, Hung-Yi Huang, Chi-Chien Lin

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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  6. Pharmaceutical Characterization andArchives of Razi Institute · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Wen-Ho ChuoDepartment of Pharmacy, Tajen University, Pingtung 907, Taiwan.ORCID 0000-0001-7884-6100
Yu-Tang TungGraduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.
Chao-Liang WuDepartment of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 600, Taiwan.ORCID 0000-0001-7821-9406
Nicole R BracciDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.ORCID 0000-0002-7298-4796
Yu-Kang ChangDepartment of Medical Research, Tungs' Taichung Metro Harbor Hospital, Taichung 433, Taiwan.
Hung-Yi HuangDepartment of Dermatology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 600, Taiwan.
Chi-Chien LinDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0002-1464-0231
Chia-Yi Christian Hospital · TWKaohsiung Medical University · TWNational Chung Hsing University · TWTajen University · TWTungs' Taichung MetroHarbor Hospital · TWVirginia–Maryland College of Veterinary Medicine · US

Funding

iEGG and Animal Biotechnology Center from the Feature Areas Research Center Program within the framework of the Higher Education Sprout Project by the Taiwan Ministry of Education MOE-107-S-0023-E
6 · The paper itself

Abstract

Psoriasis is an immune-mediated inflammatory disease that affects 2% to 3% of the world population. Alantolactone, a sesquiterpene lactone, was isolated from

Indexed as

alantolactonecytokinekeratinocytesNF-κB p65psoriasisSTAT3

Identifiers

PMID34202301
PMCPMC8303865
OpenAlexW3174210602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.