Evidence map›Paper›PMID 34202296›Full record

ArticleMolecules (Basel, Switzerland)2021

5-(Indol-2-yl)pyrazolo[3,4-

David Ramírez, Melissa Mejia-Gutierrez, Braulio Insuasty, Susanne Rinné, Aytug K Kiper, Magdalena Platzk, Thomas Müller, Niels Decher, Jairo Quiroga, Pedro De-la-Torre and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Heterocycles in Medicinal Chemistry II.Molecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

David RamírezInstituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Llano Subercaseaux 2801-Piso 5, Santiago 8900000, Chile.ORCID 0000-0003-0002-1189
Melissa Mejia-GutierrezHeterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.ORCID 0000-0002-0372-4413
Braulio InsuastyHeterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.ORCID 0000-0001-8371-3310
Susanne RinnéInstitute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.
Aytug K KiperInstitute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.ORCID 0000-0003-2850-2523
Magdalena PlatzkJoint Pulmonary Drug Discovery Lab Bayer-MGH, Boston, MA 02114, USA.
Thomas MüllerBayer AG, Research & Development, Pharmaceuticals, D-42096 Wuppertal, Germany.
Niels DecherInstitute for Physiology and Pathophysiology, Vegetative Physiology and Center for Mind, Brain and Behavior (CMBB), Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.ORCID 0000-0002-9433-687X
Jairo QuirogaHeterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A, Cali 760031, Colombia.ORCID 0000-0002-9451-3063
Pedro De-la-TorreDepartment of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear, 243 Charles St, Boston, MA 02114, USA.ORCID 0000-0002-2434-3345
Wendy GonzálezCentro de Bioinformática, Simulación y Modelado (CBSM), Facultad de Ingeniería, Universidad de Talca, Poniente No. 1141, Talca 3460000, Chile.ORCID 0000-0002-7535-6883
Philipps University of Marburg · DEUniversidad del Valle · COBayer (Germany) · DEBayer (United States) · USMassachusetts Eye and Ear Infirmary · USUniversidad Autónoma de Chile · CLUniversity of Talca · CL

Funding

Consejo Nacional de Innovación, Ciencia y Tecnología REDES190074Deutsche Forschungsgemeinschaft DE1482-4/1Fondequip EQM160063Fondo Nacional de Desarrollo Científico y Tecnológico 11180604Fondo Nacional de Desarrollo Científico y Tecnológico 1191133Iniciativa Científica Milenio, Ministry of Economy, Development and Tourism Millennium Nucleus of Ion Channels Associated Diseases (MiNICAD)on-Behring-Röntgen Stiftung 67-0015P.E. Kempkes Stiftung 05/2020
6 · The paper itself

Abstract

TASK channels belong to the two-pore-domain potassium (K

Indexed as

Molecular Docking SimulationPotassium Channel BlockersPotassium Channels, Tandem Pore DomainPyridinesHumansKCNK9 protein, humanPotassium Channel BlockersPotassium Channels, Tandem Pore DomainPyridinesdrug designmolecular dockingpharmacophorepyrazolo[3,4-b]pyridinesTASK-3 channel blockers

Identifiers

PMID34202296
PMCPMC8271858
OpenAlexW3173226617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.