Evidence map›Paper›PMID 34202286›Full record

ArticleBiomolecules2021

A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity.

Benedikt Linder, Leonhard H F Köhler, Lisa Reisbeck, Dominic Menger, Dharmalingam Subramaniam, Christel Herold-Mende, Shrikant Anant, Rainer Schobert, Bernhard Biersack, Donat Kögel

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Recent advances in piperidones as privileged scaffolds for drug discovery and development.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
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  8. Article
  9. Fluorinated andPharmaceutics · 2023
    Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Benedikt LinderExperimental Neurosurgery, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-0908-571X
Leonhard H F KöhlerOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Lisa ReisbeckExperimental Neurosurgery, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Dominic MengerExperimental Neurosurgery, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-5611-1629
Dharmalingam SubramaniamCancer Biology Department, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, MO 66160, USA.
Christel Herold-MendeDepartment of Neurosurgery, Division of Experimental Neurosurgery, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany.ORCID 0000-0002-1915-745X
Shrikant AnantCancer Biology Department, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, MO 66160, USA.ORCID 0000-0003-4193-3053
Rainer SchobertOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.ORCID 0000-0002-8413-4342
Bernhard BiersackOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.ORCID 0000-0001-7305-346X
Donat KögelExperimental Neurosurgery, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.ORCID 0000-0003-1209-0210
Goethe University Frankfurt · DEUniversity of Bayreuth · DEThe University of Kansas Cancer Center · USHeidelberg University · DE

Funding

Bitter Melon Component and Colon Cancer PreventionR01CA190291 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ANANT, SHRIKANT, UMAR, SHAHID · 2014 to 2018
$2.7M
NCI NIH HHS R01 CA190291
6 · The paper itself

Abstract

A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone curcuminoid

Indexed as

AnimalsAnimals, Genetically ModifiedAntineoplastic Agents, PhytogenicApoptosisCell ProliferationCurcuminDiarylheptanoidsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHT29 CellsHumansMCF-7 CellsZebrafishAntineoplastic Agents, PhytogenicCurcuminDiarylheptanoidsanticancer agentscell deathcurcuminfluorineglioblastomapentafluorothio grouppiperidone

Identifiers

PMID34202286
PMCPMC8301868
OpenAlexW3175126140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.