Evidence map›Paper›PMID 34202253›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Contrast Administration Impacts CT-Based Radiomics of Colorectal Liver Metastases and Non-Tumoral Liver Parenchyma Revealing the "Radiological" Tumour Microenvironment.

Francesco Fiz, Guido Costa, Nicolò Gennaro, Ludovico la Bella, Alexandra Boichuk, Martina Sollini, Letterio S Politi, Luca Balzarini, Guido Torzilli, Arturo Chiti and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06779734 (Radiomic Features of Tumor and of Liver-Tumor Interface in Patients With Colorectal Liver Metastases. Identification of New Prognostic Biomarkers.), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06779734 completednot on this map

Radiomic Features of Tumor and of Liver-Tumor Interface in Patients With Colorectal Liver Metastases. Identification of New Prognostic Biomarkers.

TypeobservationalSponsorIstituto Clinico HumanitasRan2020 to 2024Enrolled400ConditionsLiver Metastases From Colorectal Cancer (mCRC)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Francesco FizNuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Guido CostaDivision of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0003-3986-8790
Nicolò GennaroDepartment of Diagnostic Imaging, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Ludovico la BellaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20089 Milan, Italy.
Alexandra BoichukDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20089 Milan, Italy.
Martina SolliniNuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0003-2214-6492
Letterio S PolitiDepartment of Diagnostic Imaging, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-6190-6688
Luca BalzariniDepartment of Diagnostic Imaging, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Guido TorzilliDivision of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0001-5798-5021
Arturo ChitiNuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Luca ViganòDivision of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-4108-4832
Humanitas University · ITIRCCS Humanitas Research Hospital · IT

Funding

Associazione Italiana per la Ricerca sul Cancro #2019-23822
6 · The paper itself

Abstract

The impact of the contrast medium on the radiomic textural features (TF) extracted from the CT scan is unclear. We investigated the modification of TFs of colorectal liver metastases (CLM), peritumoral tissue, and liver parenchyma. One hundred and sixty-two patients with 409 CLMs undergoing resection (2017-2020) into a single institution were considered. We analyzed the following volumes of interest (VOIs): The CLM (Tumor-VOI); a 5-mm parenchyma rim around the CLM (Margin-VOI); and a 2-mL sample of parenchyma distant from CLM (Liver-VOI). Forty-five TFs were extracted from each VOI (LIFEx

Indexed as

colorectal liver metastasescomputed tomographycontrast mediumradiomicstexture analysis

Identifiers

PMID34202253
PMCPMC8305553
OpenAlexW3173633288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.