Evidence map›Paper›PMID 34202235›Full record

ArticleJournal of clinical medicine2021

Predictors of Oral Infection by Mucosal and Cutaneous Human Papillomaviruses in HIV-Infected and Uninfected Men Who Have Sex with Men of the OHMAR Study.

Massimo Giuliani, Tarik Gheit, Francesca Rollo, Massimo Tommasino, Alessandra Latini, Maria Benevolo, Barbara Pichi, Raul Pellini, Sandrine McKay-Chopin, Antonio Cristaudo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Massimo GiulianiSTI/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Tarik GheitInfections and Cancer Biology Group, International Agency for Research on Cancer, 69372 Lyon, France.
Francesca RolloPathology Department, Regina Elena National Cancer Institute IRCCS, 00144 Rome, Italy.
Massimo TommasinoInfections and Cancer Biology Group, International Agency for Research on Cancer, 69372 Lyon, France.
Alessandra LatiniSTI/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Maria BenevoloPathology Department, Regina Elena National Cancer Institute IRCCS, 00144 Rome, Italy.
Barbara PichiOtolaryngology Head&Neck Surgery Department, Regina Elena National Cancer Institute IRCCS, 00144 Rome, Italy.
Raul PelliniOtolaryngology Head&Neck Surgery Department, Regina Elena National Cancer Institute IRCCS, 00144 Rome, Italy.ORCID 0000-0001-6051-3041
Sandrine McKay-ChopinInfections and Cancer Biology Group, International Agency for Research on Cancer, 69372 Lyon, France.
Antonio CristaudoSTI/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Eugenia GiulianiScientific Direction San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Aldo MorroneScientific Direction San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Maria Gabriella DonàSTI/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.ORCID 0000-0003-3250-1726
San Gallicano Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITCentre international de recherche sur le cancer · FR

Funding

World Health Organization 001
6 · The paper itself

Abstract

Mucosal Human Papillomaviruses (HPVs) play a role in the development of a subset of head and neck cancers. Cutaneous HPVs are abundantly present in the oral cavity. The determinants of these infections have not been extensively investigated. We assessed the correlates of oral infection by alpha and beta and/or gamma HPVs in HIV-infected and uninfected men who have sex with men (MSM). Oral rinse-and-gargles were collected with a mouthwash. Alpha and beta/gamma HPVs were detected using the Linear Array HPV genotyping test and a multiplex PCR combined with Luminex technology, respectively. Multiple logistic regression was performed to identify independent predictors of oral HPV infection. Overall, 193 HIV-uninfected and 117 HIV-infected MSM were enrolled. Among HIV-infected MSM, the only determinant of alpha HPV infection was the number of lifetime oral sex partners (AOR: 8.26, 95% CI: 2.26-30.16). The strongest determinant of beta/gamma HPV infection was represented by practicing condomless receptive oral sex (AOR: 10.76, 95% CI: 1.56-74.17). Age was independently associated with alpha HPV infection in HIV-uninfected MSM. Beta/gamma HPV infection was not associated with sexual behavior in these subjects. In conclusion, predictors of oral infection differ between HIV-infected and uninfected MSM, as well as between alpha and beta/gamma HPVs.

Indexed as

cutaneousHIVHuman Papillomavirusmen who have sex with menmucosaloral cavity

Identifiers

PMID34202235
PMCPMC8269418
OpenAlexW3174504772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.