Evidence map›Paper›PMID 34202213›Full record

ArticleGenes2021

Clinicopathological and Genomic Profiles of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma Identify Overlapping Signatures with a High Mutational Burden.

Melike Ak, Abdullah Kahraman, Fabian M Arnold, Patrick Turko, Mitchell P Levesque, Martin Zoche, Egle Ramelyte, Reinhard Dummer

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Melike AkDermatology Department, University Hospital Zurich, 8091 Zurich, Switzerland.
Abdullah KahramanFaculty of Medicine, University of Zurich, 8006 Zurich, Switzerland.ORCID 0000-0003-3523-4467
Fabian M ArnoldFaculty of Medicine, University of Zurich, 8006 Zurich, Switzerland.
Patrick TurkoDermatology Department, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-3695-8264
Mitchell P LevesqueDermatology Department, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-5902-9420
Martin ZocheFaculty of Medicine, University of Zurich, 8006 Zurich, Switzerland.
Egle RamelyteDermatology Department, University Hospital Zurich, 8091 Zurich, Switzerland.
Reinhard DummerDermatology Department, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-2279-6906
University of Zurich · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare tumors developing in chronically sun-exposed skin. Clinicopathological features are similar, but they differ in prognosis, while PDS has a more aggressive course with a higher risk for local recurrence and metastases. In current clinical practice, they are diagnosed by exclusion using immunohistochemistry. Thus, stringent diagnostic criteria and correct differentiation are critical in management and treatment for optimal outcomes. This retrospective single-center study collected clinicopathological data and tumor samples of 10 AFX and 18 PDS. Extracted genomic DNA from tumor specimens was analyzed by a next-generation sequencing (NGS) platform (FoundationOne-CDx™). Among 65 identified mutations,

Indexed as

DNA Mutational AnalysisAgedAged, 80 and overBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16FemaleGene Expression Regulation, NeoplasticGenomicsHigh-Throughput Nucleotide SequencingHumansMaleMicrosatellite InstabilityMiddle AgedMutationReceptor, Notch1Repressor ProteinsASXL1 protein, humanBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16NOTCH1 protein, humanReceptor, Notch1Repressor ProteinsTelomeraseTERT protein, humanTP53 protein, humanTumor Suppressor Protein p53atypical fibroxanthomanext-generation sequencingpleomorphic dermal sarcomatumor genomic profiling

Identifiers

PMID34202213
PMCPMC8303615
OpenAlexW3174174265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.