Evidence map›Paper›PMID 34202191›Full record

ArticleMolecules (Basel, Switzerland)2021

Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials.

Giovanni Petrillo, Cinzia Tavani, Lara Bianchi, Alice Benzi, Maria Maddalena Cavalluzzi, Lara Salvagno, Laura Quintieri, Annalisa De Palma, Leonardo Caputo, Antonio Rosato and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giovanni PetrilloDepartment of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, I-16146 Genoa, Italy.ORCID 0000-0002-8182-0144
Cinzia TavaniDepartment of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, I-16146 Genoa, Italy.ORCID 0000-0003-4437-1121
Lara BianchiDepartment of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, I-16146 Genoa, Italy.
Alice BenziDepartment of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, I-16146 Genoa, Italy.
Maria Maddalena CavalluzziDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona n. 4, 70126 Bari, Italy.
Lara SalvagnoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0002-8089-001X
Laura QuintieriInstitute of Sciences of Food Production (CNR-ISPA) National Council of Research, Via G. Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0001-6261-9544
Annalisa De PalmaDepartment of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0001-6391-529X
Leonardo CaputoInstitute of Sciences of Food Production (CNR-ISPA) National Council of Research, Via G. Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0002-6370-8562
Antonio RosatoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0001-5462-4650
Giovanni LentiniDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0001-7079-5994

Funding

Università degli Studi di Genova FRA 2017
6 · The paper itself

Abstract

Twenty-two novel, variously substituted nitroazetidines were designed as both sulfonamide and urethane vinylogs possibly endowed with antimicrobial activity. The compounds under study were obtained following a general procedure recently developed, starting from 4-nitropentadienoates deriving from a common β-nitrothiophenic precursor. While being devoid of any activity against fungi and Gram-negative bacteria, most of the title compounds performed as potent antibacterial agents on Gram-positive bacteria (

Indexed as

Anti-Bacterial AgentsAzetidinesDose-Response Relationship, DrugDrug EvaluationEnterococcus faecalisHep G2 CellsHumansStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAzetidinesantibioticsdrug resistancegut microbiotavinylogy

Identifiers

PMID34202191
PMCPMC8271477

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.