ReviewInternational journal of molecular sciences2021
Hyaluronan and the Fascial Frontier.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Redefining Fascia: A Mechanobiological Hub and Stem Cell Reservoir in Regeneration-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- The Effects of Foam Rolling at Different Speeds on Mechanical Properties of Quadriceps Femoris.Journal of sports science & medicine · 2024Trial
- Detecting Intervention-Specific Change in Soft Tissue Mobility Aligned with Regional Pain Through Optically Measured Skin Surface Strains.Annals of biomedical engineering · 2026Article
- Fascial Manipulation Compared to Stretching for Rehabilitation of Children With Cerebral Palsy: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2026Article
- Polysaccharides and carbohydrate polymers: innovations from nature to industry.Journal of the science of food and agriculture · 2026Review
- Acute Oral Hydration and Thoracolumbar Fascia Stiffness in Healthy Adults.Journal of clinical medicine · 2026Article
- Local Twitches During Ultrasound-Guided Fascial Hydrorelease Occur Within Stacking Fascia: A Retrospective Analysis of a Large Video Archive.Medical sciences (Basel, Switzerland) · 2026Article
- Preliminary Comparative Analysis of Circulatory Glycosaminoglycan Concentrations and Disaccharide Profiles in Diabetic and Healthy Subjects.The Eurasian journal of medicine · 2026Article
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- The impact of stroke on intramuscular connective tissue in mice.Frontiers in neurology · 2026Article
- Myofascial release and fascial-targeted mechanical interventions in musculoskeletal rehabilitation: mechanisms, modalities, and integrative physiology.Frontiers in physiology · 2026Review
- A review of the synergistic mechanisms of Yijinjing, meridian sinew therapy, dry needling, and Fascial Manipulation in chronic cervical myofascial pain based on the fascia-meridian sinew continuum.Frontiers in medicine · 2026Review
- Fibroblasts as key effectors of acupuncture in treatment of rheumatoid arthritis.Frontiers in immunology · 2026Article
- The myofascial rheostat: hyaluronan molecular weight dynamics and purinergic signalling as a physiological feedback system.Frontiers in physiology · 2026Review
- Understanding Fascial Tissue on the Molecular Level-How Its Unique Properties Enable Adaptation or Dysfunction.International journal of molecular sciences · 2025Review
- Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes.Bioengineering (Basel, Switzerland) · 2025Article
- 3D Microstructural Characterization of Human Deep Fascia Using Optical Projection Tomography, Digital Light Sheet Microscopy, and Magnetic Resonance Microscopy.Microscopy research and technique · 2025Article
- Review
- The Natural Defense: Anti-Aging Potential of Plant-Derived Substances and Technological Solutions Against Photoaging.International journal of molecular sciences · 2025Review
- Precision targeting in acupuncture: a pilot and feasibility study protocol of ultrasound-guided approach for non-specific low back pain.Pilot and feasibility studies · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body's fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.