ArticleCancers2021
Re-Irradiation for Head and Neck Cancer: Cumulative Dose to Organs at Risk and Late Side Effects.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Radiation-Induced Carotid Artery Disease: Pathogenesis, Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- A dedicated institutional clinical workflow and peer-review meeting for reirradiation.Technical innovations & patient support in radiation oncology · 2026Article
- Accuracy of reirradiation dose constraints for the mandible and carotids.Physics and imaging in radiation oncology · 2026Article
- Multi-institutional virtual peer review for reirradiation: dedicated workflow and one-year results.Technical innovations & patient support in radiation oncology · 2025Article
- Preclinical study of reirradiation with hyperthermia in recurrent murine tumors and normal mouse skin.Acta oncologica (Stockholm, Sweden) · 2025Article
- An energy-conserving dose summation method for dose accumulation in radiotherapy.Medical physics · 2025Article
- Successful Treatment With Single-Fraction Stereotactic Body Radiotherapy to Lung and Reirradiation of Neck Node Metastases in a Treated Base Tongue Primary.Case reports in oncological medicine · 2025Article
- FLASH radiotherapy: bridging revolutionary mechanisms and clinical frontiers in cancer treatment - a narrative review.Ewha medical journal · 2024Review
- Brain Stem Glioma Recurrence: Exploring the Therapeutic Frontiers.Journal of personalized medicine · 2024Review
- Adjuvant Reirradiation With Proton Therapy in Head and Neck Squamous Cell Carcinoma.Advances in radiation oncology · 2024Article
- Re-irradiation for isolated neck recurrence in head and neck tumor: impact of rN category.Scientific reports · 2024Article
- Review and recommendations on deformable image registration uncertainties for radiotherapy applications.Physics in medicine and biology · 2023Review
- Advancements of radiotherapy for recurrent head and neck cancer in modern era.Radiation oncology (London, England) · 2023Review
- Predictors of toxicity after curative reirradiation with intensity modulated radiotherapy or proton therapy for recurrent head and neck carcinoma: new dose constraints for pharyngeal constrictors muscles and oral cavity.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Article
- Review
- Induction therapy in recurrent head and neck squamous cell carcinoma: is it time to consider response as a determinant of treatment selection?Translational cancer research · 2023Article
- Using feasibility dose-volume histograms to reduce intercampus plan quality variability for head-and-neck cancer.Journal of applied clinical medical physics · 2023Article
- Re-irradiation for head and neck cancer: outcome and toxicity analysis using a prospective single institution database.Frontiers in oncology · 2023Article
- New insights on clinical perspectives of FLASH radiotherapy: from low- to very high electron energy.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Re-irradiation in head and neck cancer is challenging, and cumulative dose constraints and dose/volume data are scarce. In this study, we present dose/volume data for patients re-irradiated for head and neck cancer and explore the correlations of cumulative dose to organs at risk and severe side effects. We analyzed 54 patients re-irradiated for head and neck cancer between 2011 and 2017. Organs at risk were delineated and dose/volume data were collected from cumulative treatment plans of all included patients. Receiver-operator characteristics (ROC) analysis assessed the association between dose/volume parameters and the risk of toxicity. The ROC-curve for a logistic model of carotid blowout vs. maximum doses to the carotid arteries showed AUC = 0.92 (95% CI 0.83 to 1.00) and a cut-off value of 119 Gy (sensitivity 1.00/specificity 0.89). The near-maximum dose to bones showed an association with the risk of osteoradionecrosis: AUC = 0.74 (95% CI 0.52 to 0.95) and a cut-off value of 119 Gy (sensitivity 1.00/specificity 0.52). Our analysis showed an association between cumulative dose to organs at risk and the risk of developing osteoradionecrosis and carotid blowout, and our results support the existing dose constraint for the carotid arteries of 120 Gy. The confirmation of these dose-response relationships will contribute to further improvements of re-irradiation strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.