ReviewAntioxidants (Basel, Switzerland)2021
Sperm Oxidative Stress during In Vitro Manipulation and Its Effects on Sperm Function and Embryo Development.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Effects of astaxanthin supplementation on human sperm quality during the freeze thaw process: a systematic review and meta analysis.Scientific reports · 2026Pooled it
- Exploring the link between periodontal disease and sperm quality: a comprehensive systematic review study.BMC oral health · 2025Pooled it
- An automatic semen processing system versus a manual method for semen processing: a randomized, single-blind non-inferiority trial.Frontiers in endocrinology · 2026Trial
- Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability.Poultry science · 2026Article
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- Industrial Hydrocarbons Exposure Deteriorates Sperm Integrity and Reproductive Function.Journal of biochemical and molecular toxicology · 2026Article
- Nanotechnology in reproductive medicine: from gamete engineering to precision therapeutics.RSC advances · 2026Review
- Reactive Oxygen Species-Induced Damage in Cryopreserved Bovine Sperm: Mitigation Strategies.Veterinary medicine and science · 2026Review
- Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system.Biological research · 2026Article
- Review
- Protective Effects of Fisetin Against Oxidative Stress in Human Sperm: Implications for Cryopreservation.Antioxidants (Basel, Switzerland) · 2026Article
- Female reproductive tract-on-a-chip for selecting sperm with ultra-low DNA fragmentation index.Microsystems & nanoengineering · 2026Article
- Oxidative Stress and Inflammatory Biomarkers in Male Infertility: A Narrative Review of Diagnostic Value and Clinical Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.Scientific reports · 2026Article
- Sperm Testing in Assisted Reproductive Technology: Diagnosis and Outcome Prediction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Effects of Caffeic Acid Supplementation on Human Sperm Against In Vitro-Induced Oxidative Stress: Nrf2 Molecular Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Protective Effect ofAntioxidants (Basel, Switzerland) · 2026Article
- Evaluation of milk-based and egg-based semen extenders for extended storage of ram semen at 4°C.Translational animal science · 2026Article
- Endocrine-metabolic modulators in sperm biotechnology: cross-species mechanisms and translational priorities.Frontiers in veterinary science · 2026Review
- Integrated ultrasonographic, endocrine, seminal, and morphological characterization of cryptorchidism in collared peccary (Animal reproduction · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) generated at low levels during mitochondrial respiration have key roles in several signaling pathways. Oxidative stress (OS) arises when the generation of ROS exceeds the cell's antioxidant scavenging ability and leads to cell damage. Physiological ROS production in spermatozoa regulates essential functional characteristics such as motility, capacitation, acrosome reaction, hyperactivation, and sperm-oocyte fusion. OS can have detrimental effects on sperm function through lipid peroxidation, protein damage, and DNA strand breakage, which can eventually affect the fertility of an individual. Substantial evidence in the literature indicates that spermatozoa experiencing OS during in vitro manipulation procedures in human- and animal-assisted reproduction are increasingly associated with iatrogenic ROS production and eventual impairment of sperm function. Although a direct association between sperm OS and human assisted reproductive techniques (ART) outcomes after in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) is still a matter of debate, studies in animal models provide enough evidence on the adverse effects of sperm OS in vitro and defective fertilization and embryo development. This review summarized the literature on sperm OS in vitro, its effects on functional ability and embryo development, and the approaches that have been proposed to reduce iatrogenic sperm damage and altered embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.