Evidence map›Paper›PMID 34202119›Full record

ReviewCells2021

Distinctive Properties and Powerful Neuromodulation of Na

Agnes Zybura, Andy Hudmon, Theodore R Cummins

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Role of NaCell reports · 2023
    Article
  13. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022
    Review
  18. Inhibition of the Akt/PKB Kinase Increases NaInternational journal of molecular sciences · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Agnes ZyburaProgram in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Andy HudmonDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Theodore R CumminsProgram in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Indiana University – Purdue University Indianapolis · USPurdue University West Lafayette · USUniversity of Indianapolis · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEARNEY, JENNIFER A · 2018 to 2022
$12.1M
Spinophilin function in regulating pathological responses to psychostimulant drugR33DA041876 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI BAUCUM, ANTHONY J. · 2018 to 2020
$1.2M
NIDA NIH HHS R33 DA041876NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability. These ion channels exist as large heteromultimeric structures and their activity is tightly controlled. In neurons, the isoform Na

Indexed as

Amino Acid SequenceAnimalsCalciumCalmodulinHumansNAV1.6 Voltage-Gated Sodium ChannelNeuronsProtein Interaction MappingProtein Processing, Post-TranslationalCalciumCalmodulinNAV1.6 Voltage-Gated Sodium Channelaction potentialaxon initial segmentchannelopathiespost-translational modificationsprotein-protein interactionssodium currentsvoltage-gated sodium channel

Identifiers

PMID34202119
PMCPMC8307729
OpenAlexW3173871475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.