ArticleSensors (Basel, Switzerland)2021
Sensitivity Analysis of Single- and Bimetallic Surface Plasmon Resonance Biosensors.
Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A Novel Surface Plasmon Resonance Imaging (SPRi) Biosensor for the Determination of Bovine Interleukin-10: Development, Validation, and Application in Biological Fluids.International journal of molecular sciences · 2025Article
- The Tunable Parameters of Graphene-Based Biosensors.Sensors (Basel, Switzerland) · 2024Article
- Comparison of Fluidic and Non-Fluidic Surface Plasmon Resonance Biosensor Variants for Angular and Intensity Modulation Measurements.Sensors (Basel, Switzerland) · 2023Article
- Sensitivity-Tunable Terahertz Liquid/Gas Biosensor Based on Surface Plasmon Resonance with Dirac Semimetal.Sensors (Basel, Switzerland) · 2023Article
- Two Biosensors for the Determination of VEGF-R2 in Plasma by Array SPRi.Molecules (Basel, Switzerland) · 2022Article
- Evaluation of Calibration Equations by Using Regression Analysis: An Example of Chemical Analysis.Sensors (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors.
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Abstract
Comparative analysis of the sensitivity of two surface plasmon resonance (SPR) biosensors was conducted on a single-metallic Au sensor and bimetallic Ag-Au sensor, using a cathepsin S sensor as an example. Numerically modeled resonance curves of Au and Ag-Au layers, with parameters verified by the results of experimental reflectance measurement of real-life systems, were used for the analysis of these sensors. Mutual relationships were determined between ∂Y/∂n components of sensitivity of the Y signal in the SPR measurement to change the refractive index n of the near-surface sensing layer and ∂n/∂c sensitivity of refractive index n to change the analyte's concentration, c, for both types of sensors. Obtained results were related to experimentally determined calibration curves of both sensors. A characteristic feature arising from the comparison of calibration curves is the similar level of Au and Ag-Au biosensors' sensitivity in the linear range, where the signal of the AgAu sensor is at a level several times greater. It was shown that the influence of sensing surface morphology on the ∂n/∂c sensitivity component had to be incorporated to explain the features of calibration curves of sensors. The shape of the sensory surface relief was proposed to increase the sensor sensitivity at low analyte concentrations.
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