Evidence map›Paper›PMID 34202033›Full record

ArticleJournal of clinical medicine2021

The Effect of Ametropia on Glaucomatous Visual Field Loss.

Eun Young Choi, Raymond C S Wong, Thuzar Thein, Louis R Pasquale, Lucy Q Shen, Mengyu Wang, Dian Li, Qingying Jin, Hui Wang, Neda Baniasadi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Eun Young ChoiSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Raymond C S WongSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Thuzar TheinSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Louis R PasqualeDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lucy Q ShenMassachusetts Eye and Ear, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0360-1296
Mengyu WangSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Dian LiSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.ORCID 0000-0002-5374-7314
Qingying JinSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.ORCID 0000-0002-7596-9137
Hui WangSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Neda BaniasadiSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.
Michael V BolandWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-2506-7095
Siamak YousefiHamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Sarah R WellikBascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33136, USA.
Carlos G De MoraesEdward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA.
Jonathan S MyersWills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Peter J BexDepartment of Psychology, Northeastern University, Boston, MA 02115, USA.
Tobias ElzeSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA.ORCID 0000-0002-2032-0496
Massachusetts Eye and Ear Infirmary · USColumbia University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USNortheastern University · USThomas Jefferson University · USUniversity of Miami · USUniversity of Tennessee Health Science Center · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Personalizing Glaucoma Diagnosis by Disease Specific Patterns and Individual Eye AnatomyR01EY030575 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2023
$2.4M
Structural and Functional Progression of Glaucomatous Damage to the MaculaR01EY025253 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE MORAES, CARLOS GUSTAVO · 2015 to 2017
$1.2M
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureR00EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2021 to 2023
$741k
Associating retinal nerve fiber layer thickness with glucose metabolism and diabetic retinopathyR21EY030631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2020
$554k
A hybrid artificial intelligence framework for glaucoma monitoringR21EY030142 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ELZE, TOBIAS, YOUSEFI, SIAMAK · 2019 to 2020
$499k
NEI NIH HHS P30 EY003790NEI NIH HHS P30EY003790NEI NIH HHS R00 EY028631NEI NIH HHS R01 EY030575NIH HHS R01EY025253NIH HHS R01EY030575NIH HHS R21EY030142NIH HHS R21EY030631
6 · The paper itself

Abstract

Myopia has been discussed as a risk factor for glaucoma. In this study, we characterized the relationship between ametropia and patterns of visual field (VF) loss in glaucoma. Reliable automated VFs (SITA Standard 24-2) of 120,019 eyes from 70,495 patients were selected from five academic institutions. The pattern deviation (PD) at each VF location was modeled by linear regression with ametropia (defined as spherical equivalent (SE) starting from extreme high myopia), mean deviation (MD), and their interaction (SE × MD) as regressors. Myopia was associated with decreased PD at the paracentral and temporal VF locations, whereas hyperopia was associated with decreased PD at the Bjerrum and nasal step locations. The severity of VF loss modulated the effect of ametropia: with decreasing MD and SE, paracentral/nasal step regions became more depressed and Bjerrum/temporal regions less depressed. Increasing degree of myopia was positively correlated with VF depression at four central points, and the correlation became stronger with increasing VF loss severity. With worsening VF loss, myopes have increased VF depressions at the paracentral and nasal step regions, while hyperopes have increased depressions at the Bjerrum and temporal locations. Clinicians should be aware of these effects of ametropia when interpreting VF loss.

Indexed as

ametropiaglaucomahyperopiamean deviationmyopiaOCTpattern deviationSITA standard 24-2spherical equivalentvisual field

Identifiers

PMID34202033
PMCPMC8268842
OpenAlexW3173546822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.