Evidence map›Paper›PMID 34202002›Full record

Trial reportBiomolecules2021

Atelocollagen-Embedded Chondrocyte Precursors as a Treatment for Grade-4 Cartilage Defects of the Femoral Condyle: A Case Series with up to 9-Year Follow-Up.

Hwa-Chang Liu, Tzu-Shang Thomas Liu, Yen-Liang Liu, Jyh-Horng Wang, Chih-Hung Chang, Tiffany Ting-Fang Shih, Feng-Huei Lin

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Hwa-Chang LiuDepartment of Orthopaedic Surgery, Taiwan Adventist Hospital, Taipei 10556, Taiwan.
Tzu-Shang Thomas LiuSouthern California Bone and Joint Clinic, Apple Valley, CA 92307, USA.
Yen-Liang LiuMaster Program for Biomedical Engineering, China Medical University, Taichung 40402, Taiwan.
Jyh-Horng WangDepartment of Orthopaedic Surgery, National Taiwan University Hospital, Taipei 10063, Taiwan.
Chih-Hung ChangDepartment of Orthopaedic Surgery, Far Eastern Memorial Hospital, New Taipei 22060, Taiwan.
Tiffany Ting-Fang ShihDepartment of Radiology, National Taiwan University Hospital, Taipei 10063, Taiwan.
Feng-Huei LinDepartment of Biomedical Engineering, National Taiwan University, Taipei 10617, Taiwan.
National Taiwan University Hospital · TWApple (United States) · USChina Medical University · TWFar Eastern Memorial Hospital · TWNational Taiwan University · TWTaiwan Adventist Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We demonstrated the safety and efficacy of autologous chondrocyte precursor (CP) cell therapy in repairing Grade 4 cartilage defects of medial femoral condyles. The autologous bone marrow mesenchymal stem cells of each participant were isolated, amplified, and then differentiated into CPs in atelocollagen. Neotissues made of CPs were implanted into cartilage defects with an average cell density of 4.9 ± 2.1 × 10

Indexed as

AgedAged, 80 and overCartilage, ArticularChondrocytesCollagenFemaleFemurFollow-Up StudiesHumansKnee JointMaleMiddle AgedTime FactorsTreatment OutcomeatelocollagenCollagencartilage regenerationchondrocyte precursormesenchymal stem cellosteoarthritisosteonecrosis

Identifiers

PMID34202002
PMCPMC8301975
OpenAlexW3173309180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.