Evidence map›Paper›PMID 34201957›Full record

ReviewGenes2021

The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction.

Lara J Monteiro, Reyna Peñailillo, Mario Sánchez, Stephanie Acuña-Gallardo, Max Mönckeberg, Judith Ong, Mahesh Choolani, Sebastián E Illanes, Gino Nardocci

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. First Trimester Placental Biomarkers for Pregnancy Outcomes.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Observational
  14. "Unraveling the Clot-Miscarriage Nexus: Mechanisms, Management, and Future Directions in Thrombosis-Related Recurrent Pregnancy Loss".Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lara J MonteiroFaculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.ORCID 0000-0003-2078-380X
Reyna PeñaililloLaboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile.ORCID 0000-0001-5300-1208
Mario SánchezMolecular Biology and Bioinformatics Lab, Program in Molecular Biology and Bioinformatics, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile.ORCID 0000-0002-5991-9930
Stephanie Acuña-GallardoFaculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Max MönckebergFaculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Judith OngYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Mahesh ChoolaniYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Sebastián E IllanesFaculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Gino NardocciFaculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.ORCID 0000-0002-2342-6480
Universidad de Los Andes, Chile · CLNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.

Indexed as

BiomarkersFemaleFetal Growth RetardationHumansPre-EclampsiaPregnancyRNA, Long NoncodingTrophoblastsBiomarkersRNA, Long Noncodingintrauterine growth restrictionlong non-coding RNAspreeclampsia

Identifiers

PMID34201957
PMCPMC8305149
OpenAlexW3175339777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.