Evidence map›Paper›PMID 34201918›Full record

ArticleInternational journal of molecular sciences2021

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N

Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Larissa HeringDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Egle KatkeviciuteDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Marlene SchwarzfischerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Anna NiechcialDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Julianne B RiggsDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Marcin WawrzyniakDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Kirstin AtrottDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Marnix van de SandeDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Silvia LangDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.ORCID 0000-0002-1216-899X
Burkhard BecherInstitute of Experimental Immunology, University of Zurich, 8091 Zurich, Switzerland.
Gerhard RoglerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Michael ScharlDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Marianne R SpalingerDepartment of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.ORCID 0000-0003-4498-0058
University of Zurich · CH

Funding

Novartis Foundation for Biomedical Research n/aSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 314730-146204, 314730_166381 320030_184753Stiftung Experimentelle Biomedizin n/athe Holcim Foundation for the Advancement of Science n/a
6 · The paper itself

Abstract

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolled immune responses. The effect of DC-specific PTPN2 loss on intestinal health, however, is unknown. The aim of this study was to investigate the DC-specific role of PTPN2 in the intestine during colitis development. PTPN2

Indexed as

AnimalsColitisDendritic CellsDextran SulfateDisease Models, AnimalDisease SusceptibilityIntestinal MucosaMacrophagesMiceMice, TransgenicPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 2Severity of Illness IndexSignal TransductionSTAT1 Transcription FactorT-Lymphocyte SubsetsDextran SulfateProtein Tyrosine Phosphatase, Non-Receptor Type 2Ptpn2 protein, mouseStat1 protein, mouseSTAT1 Transcription Factorcolitisdendritic cellsinflammatory bowel diseasePTPN2

Identifiers

PMID34201918
PMCPMC8269284
OpenAlexW3173925692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.