Evidence map›Paper›PMID 34201851›Full record

ArticleCells2021

Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice.

Tomoe Yashiro, Hanako Ogata, Syed Faisal Zaidi, Jaemin Lee, Shusaku Hayashi, Takeshi Yamamoto, Makoto Kadowaki

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Sensory signals for nausea.Trends in neurosciences · 2025
    Review
  5. Review
  6. Review
  7. Neuroimmune Interactions in the Intestine.Annual review of immunology · 2024
    Review
  8. Article
  9. Review
  10. The enteric nervous system.Physiological reviews · 2023
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tomoe YashiroDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Hanako OgataDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Syed Faisal ZaidiDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0002-2668-1997
Jaemin LeeDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Shusaku HayashiDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0002-8304-7255
Takeshi YamamotoDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0002-4383-6954
Makoto KadowakiDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
University of Toyama · JP

Funding

Japan Society for the Promotion of Science 18K06698Japan Society for the Promotion of Science 19K07908Japan Society for the Promotion of Science 20K07098Smoking Research Foundation 2015T001Smoking Research Foundation 2020T003
6 · The paper itself

Abstract

Recently, the involvement of the nervous system in the pathology of allergic diseases has attracted increasing interest. However, the precise pathophysiological role of enteric neurons in food allergies has not been elucidated. We report the presence of functional high-affinity IgE receptors (FcεRIs) in enteric neurons. FcεRI immunoreactivities were observed in approximately 70% of cholinergic myenteric neurons from choline acetyltransferase-eGFP mice. Furthermore, stimulation by IgE-antigen elevated intracellular Ca

Indexed as

Cell CommunicationAdenosineAdenosine A3 Receptor AntagonistsAnimalsAntigensBone Marrow CellsCells, CulturedEnteric Nervous SystemFood HypersensitivityIntestinal MucosaIntracellular SpaceMaleMast CellsMiceMice, Inbred BALB CMice, Inbred C57BLAdenosineAdenosine A3 Receptor AntagonistsAntigensReceptor, Adenosine A3Receptors, IgERNA, Messengeradenosineenteric neuronFcεRIfood allergymucosal mast cellneuro-immune interaction

Identifiers

PMID34201851
PMCPMC8305700
OpenAlexW3176414017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.