Evidence map›Paper›PMID 34201821›Full record

Trial reportNutrients2021

Effect of Fortification with Multiple Micronutrient Powder on the Prevention and Treatment of Iron Deficiency and Anaemia in Brazilian Children: A Randomized Clinical Trial.

Malaine Morais Alves Machado, Mirella de Paiva Lopes, Raquel Machado Schincaglia, Paulo Sérgio Sucasas da Costa, Alexandre Siqueira Guedes Coelho, Maria Claret Costa Monteiro Hadler

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Efficacy and Safety of Multiple Micronutrient (MMN) Supplementation on Anemia in Children and Adults (Except Pregnant Women): A Meta-Analysis.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Malaine Morais Alves MachadoGraduate Program in Health Sciences of the Federal University of Goiás, Faculty of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.
Mirella de Paiva LopesFaculty of Nutrition, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.
Raquel Machado SchincagliaResearch Laboratory in Clinical and Sports Nutrition, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.
Paulo Sérgio Sucasas da CostaDepartment of Pediatrics, School of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.ORCID 0000-0001-9370-9139
Alexandre Siqueira Guedes CoelhoGraduate Program in Nutrition and Health of the Federal University of Goiás, Faculty of Nutrition Goiânia, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.
Maria Claret Costa Monteiro HadlerGraduate Program in Health Sciences of the Federal University of Goiás, Faculty of Medicine, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.ORCID 0000-0003-0631-8629

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408786/2017-5Fundação de Amparo à Pesquisa do Estado de Goiás 201710267001247
6 · The paper itself

Abstract

Fortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and treatment of iron deficiency and anaemia. This was a cluster trial with anemic and non-anaemic children between six and 42 months old, in randomization data. Non anaemic children received fortification with multiple micronutrient powder or standard drug supplementation of ferrous sulfate associated with folic acid in a prevention dose. Anaemic children who were randomized to receive multiple micronutrient powder also received the recommended iron complementation for anaemia treatment. A total of 162 children were evaluated. The prevalence of anaemia decreased from 13.58 to 1.85%. Iron deficiency decreased from 21.74% to 7.89% (by serum ferritin) and iron deficiency decreased from 66.81 to 38.27% (by soluble transferrin receptor). No difference was identified between interventions for hemoglobin (

Indexed as

Food, FortifiedAnemia, Iron-DeficiencyBrazilChild, PreschoolFemaleFerritinsHemoglobinsHumansInfantMaleMicronutrientsPowdersPrevalenceFerritinsHemoglobinsMicronutrientsPowdersanaemiachildrendeficiency diseasesiron deficiencymicronutrients

Identifiers

PMID34201821
PMCPMC8308208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.