Evidence map›Paper›PMID 34201801›Full record

ArticleToxins2021

Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in

John K Crane, Mashal Salehi, Cassandra L Alvarado

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Inhibition of SOS Response by Nitric Oxide Donors inFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John K CraneDepartment of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, NY 14221, USA.
Mashal SalehiDepartment of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, NY 14221, USA.
Cassandra L AlvaradoDepartment of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, NY 14221, USA.
University at Buffalo, State University of New York · US

Funding

The SOS Response as a Generator of Antibiotic Resistance and Role of Zinc as SOS InhibitorR21AI145836 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CRANE, JOHN K. · 2019 to 2020
$435k
National Institute of Allergy and Infectious Diseases R21 AI 145836
6 · The paper itself

Abstract

Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties. We considered whether psychoactive drugs induce the SOS response in

Indexed as

Antipsychotic Agentsbeta-GalactosidaseSelective Serotonin Reuptake InhibitorsShiga-Toxigenic Escherichia coliShiga Toxin 2SOS Response, GeneticsAntipsychotic Agentsbeta-GalactosidaseSelective Serotonin Reuptake InhibitorsShiga Toxin 2enterohemorrhagic E. colihemolytic-uremic syndromehypermutationphenothiazinesRecAserotonin selective reuptake inhibitorsShiga-toxigenic E. coli

Identifiers

PMID34201801
PMCPMC8309737
OpenAlexW3176082688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.