Evidence map›Paper›PMID 34201747›Full record

ArticleInternational journal of molecular sciences2021

Treatment with the Bacterial Toxin CNF1 Selectively Rescues Cognitive and Brain Mitochondrial Deficits in a Female Mouse Model of Rett Syndrome Carrying a MeCP2-Null Mutation.

Chiara Urbinati, Livia Cosentino, Elena Angela Pia Germinario, Daniela Valenti, Daniele Vigli, Laura Ricceri, Giovanni Laviola, Carla Fiorentini, Rosa Anna Vacca, Alessia Fabbri and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chiara UrbinatiCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Livia CosentinoCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Elena Angela Pia GerminarioDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-1312-7476
Daniela ValentiBioenergetics and Molecular Biotechnologies, Institute of Biomembranes, National Council of Research, 70126 Bari, Italy.
Daniele VigliCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Laura RicceriCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Giovanni LaviolaCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-0388-0835
Carla FiorentiniAssociation for Research on Integrative Oncology Therapies (ARTOI), 00165 Rome, Italy.ORCID 0000-0003-1707-6282
Rosa Anna VaccaBioenergetics and Molecular Biotechnologies, Institute of Biomembranes, National Council of Research, 70126 Bari, Italy.ORCID 0000-0003-2438-6449
Alessia FabbriDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-3075-3367
Bianca De FilippisCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-6508-1206
Istituto Superiore di Sanità · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · IT

Funding

International Rett syndrome Foundation (USA) #3107Italian Ministry of Health (Italy) #GR-2018-12366210Jerome Lejeune Foundation (France) (no number)
6 · The paper itself

Abstract

Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked

Indexed as

AnimalsBacterial ToxinsBrainDisease Models, AnimalEscherichia coli ProteinsFearFemaleInfusions, IntraventricularLoss of Function MutationMemory DisordersMethyl-CpG-Binding Protein 2MiceMice, Mutant StrainsMicrofilament ProteinsMitochondriaNerve Tissue ProteinsBacterial Toxinscytotoxic necrotizing factor type 1Escherichia coli ProteinsMecp2 protein, mouseMethyl-CpG-Binding Protein 2Microfilament ProteinsmTOR protein, mouseNerve Tissue ProteinsNeurabinsTOR Serine-Threonine Kinasesbehaviourcognitionenergy metabolismmitochondriamouse modelsmTORRett syndromeRho GTPases

Identifiers

PMID34201747
PMCPMC8269120
OpenAlexW3175675832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.