Evidence map›Paper›PMID 34201725›Full record

ArticleJournal of clinical medicine2021

Feasibility of Secondary Follicle Isolation, Culture and Achievement of In-Vitro Oocyte Maturation from Superovulated Ovaries: An Experimental Proof-of-Concept Study Using Mice.

Xia Hao, Amandine Anastácio, Kenny A Rodriguez-Wallberg

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xia HaoDepartment of Oncology and Pathology, Karolinska Institutet, Solna, SE-171 76 Stockholm, Sweden.
Amandine AnastácioDepartment of Oncology and Pathology, Karolinska Institutet, Solna, SE-171 76 Stockholm, Sweden.
Kenny A Rodriguez-WallbergDepartment of Oncology and Pathology, Karolinska Institutet, Solna, SE-171 76 Stockholm, Sweden.ORCID 0000-0003-4378-6181
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

Barncancerfonden PR2016-0115, PR2020-0136Cancerfonden CAN 2017/704, 20 0170 FRadiumhemmets Research Funds Grant for clinical researchers 2020-2025the Karolinska Institutet Research grants in pediatrics from the Birgitta and Carl-Axel Rydbeck Donation 2020-00339the Stockholm County Council FoUI-953912Vetenskapsrådet Dnr 2020-02230
6 · The paper itself

Abstract

Fertility preservation through ovarian stimulation, aiming at cryopreserving mature oocytes or embryos, is sometimes unsuccessful. This clinical situation deserves novel approaches to overcome infertility following cancer treatment in patients facing highly gonadotoxic treatment. In this controlled experimental study, we investigated the feasibility of in-vitro culturing secondary follicles isolated from superovulated ovaries of mice recently treated with gonadotropins. The follicle yields of superovulated ovaries were 45.9% less than in unstimulated controls. Follicles from superovulated ovaries showed faster growth pace during the initial 7 days of culture and secreted more 17β-estradiol by the end of culture

Indexed as

female fertility preservationfollicle isolationin-vitro maturationovarian tissuesecondary follicle culturesuperovulation

Identifiers

PMID34201725
PMCPMC8268951
OpenAlexW3174649887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.