Evidence map›Paper›PMID 34201691›Full record

ArticleVaccines2021

Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide.

Giulia Franzoni, Antonio Anfossi, Chiara Grazia De Ciucis, Samanta Mecocci, Tania Carta, Silvia Dei Giudici, Floriana Fruscione, Susanna Zinellu, Guendalina Vito, Simon Paul Graham and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Giulia FranzoniDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0003-0987-3863
Antonio AnfossiSchool of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4954-9702
Chiara Grazia De CiucisNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, Italy.
Samanta MecocciDepartment of Veterinary Medicine, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-2998-0412
Tania CartaDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Silvia Dei GiudiciDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0003-1803-4666
Floriana FruscioneNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, Italy.
Susanna ZinelluDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Guendalina VitoNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, Italy.
Simon Paul GrahamThe Pirbright Institute, Ash Road, Pirbright, Woking GU24 ONF, UK.ORCID 0000-0003-4852-405X
Annalisa OggianoDepartment of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0002-3167-0942
Bernardo ChessaSchool of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.
Elisabetta RazzuoliNational Reference Center of Veterinary and Comparative Oncology (CEROVEC), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39/24, 16129 Genoa, Italy.ORCID 0000-0002-6597-475X
Istituto Zooprofilattico Sperimentale della Sardegna · ITIstituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta · ITUniversity of Sassari · ITThe Pirbright Institute · GBUniversity of Perugia · IT

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007031Italian Ministry of Health grant IZS PLV 08/19 RCItalian Ministry of Health grant IZSUM PSRC 1/2018
6 · The paper itself

Abstract

Toll-like receptor 2 (TLR2) ligands are attracting increasing attention as prophylactic and immunotherapeutic agents against pathogens and tumors. We previously observed that a synthetic diacylated lipopeptide based on a surface protein of

Indexed as

cytokinesIFN-α subtypesIL-10macrophagespigsurface markersTLR2 agonisttoll-like receptors

Identifiers

PMID34201691
PMCPMC8310132
OpenAlexW3175466398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.