Evidence map›Paper›PMID 34201585›Full record

ArticleInternational journal of molecular sciences2021

MicroRNA 195-5p Targets

Yinshan Bai, Bo Pan, Xiaoshu Zhan, Hailey Silver, Julang Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  7. Nuclear miRNAs: Gene Regulation Activities.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Yinshan BaiDepartment of Life Science and Engineering, Foshan University, Foshan 528225, China.
Bo PanDepartment of Animal BioSciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-0984-2058
Xiaoshu ZhanDepartment of Life Science and Engineering, Foshan University, Foshan 528225, China.
Hailey SilverDepartment of Animal BioSciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Julang LiDepartment of Animal BioSciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Foshan University · CNUniversity of Guelph · CANational Heart Lung and Blood Institute · US

Funding

Natural Sciences and Engineering Research Council of Canada,and the Food from Thought Program,University of Guelph CRDPJ470408-14
6 · The paper itself

Abstract

Forkhead box O3 (Foxo3) is a member of the FOXO subfamily within the forkhead box (FOX) family, which has been shown to be essential for ovarian follicular development and maturation. Previous studies have shown the abundant expression of miR-195-5p in the nuclei of porcine granulosa cells (GCs), suggesting its potential role during ovarian follicle growth. In this study, a conditional immortalized porcine granulosa cell (CIPGC) line was used to determine whether the expression of Foxo3 could be regulated by the nuclear-enriched miR-195-5p. Through silico target prediction, we identified a potential binding site of miR-195-5p within the

Indexed as

AnimalsArgonaute ProteinsBinding SitesCell LineCell NucleusChromatin ImmunoprecipitationEpigenesis, GeneticFemaleForkhead Box Protein O3Gene Expression RegulationGranulosa CellsHistonesMicroRNAsPromoter Regions, GeneticSwineValproic AcidArgonaute ProteinsForkhead Box Protein O3HistonesMicroRNAsMIRN195 microRNA, humanValproic Acidcell nuclearepigenetic regulation AGOFoxo3granulosamiRNAmRNAnucleartranscription

Identifiers

PMID34201585
PMCPMC8267755
OpenAlexW3174559529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.