Evidence map›Paper›PMID 34201475›Full record

ArticleJournal of personalized medicine2021

Reduction in and Preventive Effects for Oral-Cancer Risk with Antidepressant Treatment.

Chia-Min Chung, Tzer-Min Kuo, Kun-Tu Yeh, Chien-Hung Lee, Ying-Chin Ko

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chia-Min ChungCenter for Drug Abuse and Addiction, China Medical University Hospital, Taichung 40447, Taiwan.ORCID 0000-0003-1759-2279
Tzer-Min KuoEnvironment-Omics-Diseases Research Centre, China Medical University Hospital, China Medical University, No. 2 Yude Road, Taichung 40447, Taiwan.
Kun-Tu YehDepartment of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan.ORCID 0000-0003-0665-8586
Chien-Hung LeeDepartment of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-0988-264X
Ying-Chin KoEnvironment-Omics-Diseases Research Centre, China Medical University Hospital, China Medical University, No. 2 Yude Road, Taichung 40447, Taiwan.ORCID 0000-0002-7713-9487
China Medical University · TWChanghua Christian Hospital · TWKaohsiung Medical University · TW

Funding

Ministry of Science and Technology MOST106-2314-B-039-016-MY3
6 · The paper itself

Abstract

Areca nut (AN) was identified as carcinogenic to humans. Around 600 million people globally use AN in some form, yet no effective therapeutic drug is available to overcome AN addiction. This preclinical study examines the effects of antidepressants on AN use with animal models. We produced AN powder and dissolved it into drinking water, training 55 C57BL/6 mice in free self-selection to drink AN water or normal water. Then, the mice were randomly divided into four groups. Selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and

Indexed as

antidepressantsareca nutbetel quidmouse modeloral canceroral submucous fibrosis

Identifiers

PMID34201475
PMCPMC8307663
OpenAlexW3176439361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.