Evidence map›Paper›PMID 34201473›Full record

ArticleHealthcare (Basel, Switzerland)2021

Diabetes Mellitus-A Risk Factor for Unfavourable Outcome in COVID-19 Patients-The Experience of an Infectious Diseases Regional Hospital.

Egidia Miftode, Larisa Miftode, Ioana Coman, Cristian Prepeliuc, Maria Obreja, Oana Stămăteanu, Tudorița Gabriela Părângă, Daniela Leca, Claudia Elena Pleşca

Open access · goldAbstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. The Clash of the Titans: COVID-19, Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Predictors of COVID-19 severity among pregnant patients.Bosnian journal of basic medical sciences · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Egidia Miftode"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Larisa Miftode"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Ioana Coman"Saint Parascheva", Infectious Diseases Clinical Universitary Hospital Iasi, 700116 Iasi, Romania.
Cristian Prepeliuc"Saint Parascheva", Infectious Diseases Clinical Universitary Hospital Iasi, 700116 Iasi, Romania.
Maria Obreja"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Oana Stămăteanu"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Tudorița Gabriela Părângă"Saint Parascheva", Infectious Diseases Clinical Universitary Hospital Iasi, 700116 Iasi, Romania.
Daniela Leca"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Claudia Elena Pleşca"Grigore T. Popa", University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania.
Grigore T. Popa University of Medicine and Pharmacy · ROSpitalul Clinic C.F. Iasi · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early research into the implications concerning the evolution of the infection caused by the new coronavirus in people with glucose metabolism dysfunction, in this case diabetics, shows that severe forms of the disease predominate in this risk category. Moreover, it seems that even in patients with normal glycaemic status, COVID-19 may predispose to the development of hyperglycaemia which modulates immune mechanisms and inflammatory responses, with direct effects on morbidity and mortality. Thus, taking into account these scientific data, as well as the increased frequency of diabetes in the general population, we aimed to assess the risk of an unfavourable outcome of diabetic patients, which is in a strong connection with the presence and severity of pulmonary disease such as interstitial pneumonia/bronchopneumonia, as well as the effectiveness of Tocilizumab administration. The results of our study indicate a three-fold higher risk of death in patients with diabetes and COVID-19 (RR = 3.03; IC95%: 2.37-3.86;

Indexed as

COVID-19cytokine stormdiabetes mellitus

Identifiers

PMID34201473
PMCPMC8306222
OpenAlexW3174643717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.