Evidence map›Paper›PMID 34201422›Full record

ArticleMolecules (Basel, Switzerland)2021

Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core.

Marco A Almaraz-Girón, Ernesto Calderón-Jaimes, Adrián Sánchez Carrillo, Erik Díaz-Cervantes, Edith Castañón Alonso, Alejandro Islas-Jácome, Armando Domínguez-Ortiz, Sandra L Castañón-Alonso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Synthesis of bis-furyl-pyrrolo[3,4-RSC medicinal chemistry · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marco A Almaraz-GirónDepartament de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México C.P. 09340, Mexico.
Ernesto Calderón-JaimesLaboratory de Investigación en Inmunoquímica, Unidad de Investigación en Inmunología Proteómica, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez Nº 162, Col. Doctores, Delegación Cuauhtémoc, Ciudad de México C.P. 06720, Mexico.
Adrián Sánchez CarrilloLaboratory de Investigación en Inmunoquímica, Unidad de Investigación en Inmunología Proteómica, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez Nº 162, Col. Doctores, Delegación Cuauhtémoc, Ciudad de México C.P. 06720, Mexico.
Erik Díaz-CervantesCentro Interdisciplinario del Noreste, Departament de Alimentos, Universidad de Guanajuato, Tierra Blanca, Guanajuato C.P. 37975, Mexico.ORCID 0000-0002-1746-3795
Edith Castañón AlonsoLaboratory de Investigación en Inmunoquímica, Unidad de Investigación en Inmunología Proteómica, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez Nº 162, Col. Doctores, Delegación Cuauhtémoc, Ciudad de México C.P. 06720, Mexico.
Alejandro Islas-JácomeDepartament de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México C.P. 09340, Mexico.ORCID 0000-0003-0975-5904
Armando Domínguez-OrtizDepartament de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México C.P. 09340, Mexico.
Sandra L Castañón-AlonsoDepartament de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México C.P. 09340, Mexico.
Universidad Autónoma Metropolitana · MXHospital Infantil de México Federico Gómez · MXUniversidad de Guanajuato · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A possible inhibitor of proteases, which contains an indole core and an aromatic polar acetylene, was designed and synthesized. This indole derivative has a molecular architecture kindred to biologically relevant species and was obtained through five synthetic steps with an overall yield of 37% from the 2,2'-(phenylazanediyl)di(ethan-1-ol). The indole derivative was evaluated through docking assays using the main protease (SARS-CoV-2-M

Indexed as

AcetyleneAntineoplastic AgentsAntiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug DiscoveryHumansHydrogen BondingHydrophobic and Hydrophilic InteractionsIndolesKallikreinsModels, MolecularMolecular Docking SimulationProtease InhibitorsSARS-CoV-2AcetyleneAntineoplastic AgentsAntiviral AgentsCoronavirus 3C ProteasesIndolesKallikreinsKLK5 protein, humanProtease Inhibitorsdocking studiesindole derivativesinhibitor of proteasesKLK5 proteaseSARS-CoV-2-Mprostudies in silicosynthesis

Identifiers

PMID34201422
PMCPMC8270299
OpenAlexW3174652247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.