Evidence map›Paper›PMID 34201416›Full record

ArticleInternational journal of molecular sciences2021

Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice.

Lu Xu, Hua Song, Qi Qiu, Ting Jiang, Pingyun Ge, Zaiji Su, Wenhui Ma, Ran Zhang, Caihua Huang, Shanhua Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lu XuInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.ORCID 0000-0002-5904-5495
Hua SongFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.ORCID 0000-0003-1042-1776
Qi QiuInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.
Ting JiangKey Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Pingyun GeFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Zaiji SuFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Wenhui MaInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.
Ran ZhangInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.
Caihua HuangResearch and Communication Center of Exercise and Health, Xiamen University of Technology, Xiamen 361024, China.
Shanhua LiInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.
Donghai LinFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Jiaxing ZhangInstitute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China.
Xiamen University · CNXiamen University of Technology · CN

Funding

the National Natural Science Foundation of China 81471630; 81871519
6 · The paper itself

Abstract

Hypoxia is associated with clinical diseases. Extreme hypoxia leads to multiple organs failure. However, the different effects of hypoxia on brain and visceral organs still need to be clarified, and moreover, characteristics in vulnerable organs suffering from hypoxia remain elusive. In the present study, we first aimed to figure out the hypoxic sensitivity of organs. Adult male mice were exposed to 6% O

Indexed as

AnimalsBehavior, AnimalBlotting, WesternBrainCarbocyaninesHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKidneyLiverMagnetic Resonance SpectroscopyMaleMiceMice, Inbred BALB CMolecular ImagingNanocompositesCarbocyaninesCY5.5 cyanine dyeHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitbrainHIF-1αhypoxiakidneylivermetabolism

Identifiers

PMID34201416
PMCPMC8268807
OpenAlexW3176095245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.