Evidence map›Paper›PMID 34201333›Full record

ReviewPharmaceutics2021

Smart Nanoparticles for Chemo-Based Combinational Therapy.

Binita Shrestha, Lijun Wang, Eric M Brey, Gabriela Romero Uribe, Liang Tang

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Advanced biomedical research · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Smart Nanocarrier-Based Cancer Therapeutics.Cancer treatment and research · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. Functionalized Poly(Gels (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Binita ShresthaDepartment of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Lijun WangDepartment of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Eric M BreyDepartment of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0001-8766-7390
Gabriela Romero UribeDepartment of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0001-8081-2946
Liang TangDepartment of Biomedical and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.

Funding

Non-invasive Excitation and Inhibition of Neural Activity via On-Demand Magnetothermal Drug ReleaseSC1GM130542 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI ROMERO URIBE, GABRIELA · 2019 to 2022
$1.0M
NIGMS NIH HHS SC1 GM130542NIGMS NIH HHS SC1GM130542NIH HHS 5R01EB020604
6 · The paper itself

Abstract

Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

Indexed as

cancerchemotherapycombinationalmulti-functionalsmart nanoparticlesstimuli-responsivetreatment

Identifiers

PMID34201333
PMCPMC8227511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.