Evidence map›Paper›PMID 34201304›Full record

ArticleMembranes2021

Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in

Wen Liu, Hao Cao, Moses Kimari, Georgios Maronitis, Michael J Williams, Helgi B Schiöth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. ame-miR-34 Modulates the Larval Body Weight and Immune Response ofInternational journal of molecular sciences · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Wen LiuFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Hao CaoFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Moses KimariFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Georgios MaronitisFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Michael J WilliamsFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Helgi B SchiöthFunctional Pharmacology, Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Uppsala University · SE

Funding

Cancerfonden 20 0990 PjHorizon 2020 857394Svenska Forskningsrådet Formas 2018-00738Vetenskapsrådet 2018-03238
6 · The paper itself

Abstract

Multidrug resistance proteins (MRPs), members of the ATP-binding cassette transporter (ABC transporter) family, are pivotal for transporting endo- and xenobiotics, which confer resistance to anticancer agents and contribute to the clearance of oxidative products. However, their function in many biological processes is still unclear. We investigated the role of an evolutionarily conserved MRP in metabolic homeostasis by knocking down the expression of

Indexed as

ABCC1kidneylipid metabolismoxidative stressxenobiotic

Identifiers

PMID34201304
PMCPMC8229909
OpenAlexW2895768005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.