Evidence map›Paper›PMID 34201183›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

Development of a Simple and Robust Whole Blood Assay with Dual Co-Stimulation to Quantify the Release of T-Cellular Signature Cytokines in Response to

Chris D Lauruschkat, Lukas Page, P Lewis White, Sonja Etter, Helen E Davies, Jamie Duckers, Frank Ebel, Elisabeth Schnack, Matthijs Backx, Mariola Dragan and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  7. Review
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  10. Article
  11. Chronic Occupational Mold Exposure Drives Expansion ofJournal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Chris D LauruschkatDepartment of Internal Medicine II, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Lukas PageDepartment of Internal Medicine II, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
P Lewis WhitePublic Health Wales, Microbiology Cardiff, Wales CF14 4XW, UK.
Sonja EtterDepartment of Internal Medicine II, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Helen E DaviesDepartment of Respiratory Medicine, University Hospital of Wales, Llandough Site, Cardiff CF64 2XX, UK.
Jamie DuckersCystic Fibrosis Unit, University Hospital of Wales, Llandough Site, Cardiff CF64 2XX, UK.
Frank EbelInstitute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-University of Munich, 80539 Munich, Germany.ORCID 0000-0002-1027-1440
Elisabeth SchnackInstitute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-University of Munich, 80539 Munich, Germany.
Matthijs BackxPublic Health Wales, Microbiology Cardiff, Wales CF14 4XW, UK.
Mariola DraganDepartment of Surgery I, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Nicolas SchlegelDepartment of Surgery I, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0001-5705-3945
Olaf KniemeyerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute (HKI), 07745 Jena, Germany.
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute (HKI), 07745 Jena, Germany.
Hermann EinseleDepartment of Internal Medicine II, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-7680-0819
Juergen LoefflerDepartment of Internal Medicine II, University Hospital of Wuerzburg, 97080 Wuerzburg, Germany.
Sebastian WursterDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-7784-7256
Universitätsklinikum Würzburg · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DELudwig-Maximilians-Universität München · DEPublic Health Wales · GBUniversity Hospital of Wales · GBThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deeper understanding of mold-induced cytokine signatures could promote advances in the diagnosis and treatment of invasive mycoses and mold-associated hypersensitivity syndromes. Currently, most T-cellular immunoassays in medical mycology require the isolation of mononuclear cells and have limited robustness and practicability, hampering their broader applicability in clinical practice. Therefore, we developed a simple, cost-efficient whole blood (WB) assay with dual α-CD28 and α-CD49d co-stimulation to quantify cytokine secretion in response to

Indexed as

adaptive immunityAspergillusbiomarkercytokinesimmunoassayinflammation

Identifiers

PMID34201183
PMCPMC8230040
OpenAlexW3170105438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.