Evidence map›Paper›PMID 34201173›Full record

ArticleInternational journal of molecular sciences2021

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication.

Viktoriya Rumyantceva, Valeriya Rumyantceva, Yulia Andreeva, Sofia Tsvetikova, Anton Radaev, Maria Vishnevskaya, Vladimir Vinogradov, Andrey S Drozdov, Elena Koshel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The role of nanocomposites against biofilm infections in humans.Frontiers in cellular and infection microbiology · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Viktoriya RumyantcevaInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.
Valeriya RumyantcevaInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.
Yulia AndreevaInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.
Sofia TsvetikovaInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.ORCID 0000-0003-0580-9522
Anton RadaevChromas Research Resource Center, St. Petersburg State University, 199034 St. Petersburg, Russia.
Maria VishnevskayaChromas Research Resource Center, St. Petersburg State University, 199034 St. Petersburg, Russia.ORCID 0000-0002-2634-2610
Vladimir VinogradovInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.ORCID 0000-0002-5081-4876
Andrey S DrozdovInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.ORCID 0000-0001-7260-3095
Elena KoshelInternational Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia.ORCID 0000-0002-8957-5956

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of

Indexed as

MagneticsAnti-Bacterial AgentsBiofilmsCarbonatesCiprofloxacinDrug CarriersDrug Delivery SystemsEscherichia coliNanocompositesStaphylococcus aureusAnti-Bacterial AgentsCarbonatesCiprofloxacinDrug Carriersantibioticantimicrobial effectbiofilmmagnetitenanocomposite

Identifiers

PMID34201173
PMCPMC8229197

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.