Evidence map›Paper›PMID 34200991›Full record

ReviewCells2021

Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration.

Kevin Y Zhang, Erika A Aguzzi, Thomas V Johnson

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025
    Review
  9. Review
  10. Review
  11. A miR-383-5p Signaling Hub Coordinates the Axon Regeneration Response to Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Review
  13. Tissue Engineering and Ophthalmology.Turkish journal of ophthalmology · 2024
    Review
  14. Article
  15. Review
  16. Seeing the Future: A Review of Ocular Therapy.Bioengineering (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Mesenchymal stem cells for repairing glaucomatous optic nerve.International journal of ophthalmology · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kevin Y ZhangGlaucoma Center for Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee B-110, Baltimore, MD 21287, USA.
Erika A AguzziGlaucoma Center for Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee B-110, Baltimore, MD 21287, USA.
Thomas V JohnsonGlaucoma Center for Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee B-110, Baltimore, MD 21287, USA.ORCID 0000-0002-5372-5457
Johns Hopkins University · US

Funding

Transplantation of human stem cell-derived neurons for retinal ganglion cell replacement and optic nerve regeneration.K08EY031801 · NEI · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, THOMAS VINCENT · 2020 to 2024
$945k
NEI NIH HHS K08 EY031801
6 · The paper itself

Abstract

As part of the central nervous system, mammalian retinal ganglion cells (RGCs) lack significant regenerative capacity. Glaucoma causes progressive and irreversible vision loss by damaging RGCs and their axons, which compose the optic nerve. To functionally restore vision, lost RGCs must be replaced. Despite tremendous advancements in experimental models of optic neuropathy that have elucidated pathways to induce

Indexed as

Nerve RegenerationAnimalsHumansNeuroprotectionRegenerative MedicineRetinal Ganglion CellsStem Cell Transplantationcell replacementengraftmentfunctional integrationneuronoptic nerveregenerationregenerative medicineretinal ganglion cellstem cellstransplantation

Identifiers

PMID34200991
PMCPMC8228580
OpenAlexW3171993855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.