Evidence map›Paper›PMID 34200908›Full record

ArticleNutrients2021

Free and Total Amino Acids in Human Milk in Relation to Maternal and Infant Characteristics and Infant Health Outcomes: The Ulm SPATZ Health Study.

Joris H J van Sadelhoff, Linda P Siziba, Lisa Buchenauer, Marko Mank, Selma P Wiertsema, Astrid Hogenkamp, Bernd Stahl, Johan Garssen, Dietrich Rothenbacher, Jon Genuneit

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026
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  6. Observational
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Joris H J van SadelhoffDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-4416-3114
Linda P SizibaPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-4773-252X
Lisa BuchenauerPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.
Marko MankDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.ORCID 0000-0001-7695-3906
Selma P WiertsemaDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.
Astrid HogenkampDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.
Bernd StahlDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.
Johan GarssenDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-8678-9182
Dietrich RothenbacherInstitute of Epidemiology and Medical Biometry, Ulm University, 89079 Ulm, Germany.ORCID 0000-0002-3563-2791
Jon GenuneitPediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0001-5764-1528
Utrecht University · NLDanone (Netherlands) · NLLeipzig University · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Free amino acids (FAAs) are important regulators of key pathways necessary for growth, development, and immunity. Data on FAAs in human milk (HM) and their roles in infant development are limited. We investigated the levels of FAAs and total amino acids (TAA, i.e., the sum of conjugated amino acids and FAAs) in HM in relation to infant and maternal characteristics and immunological conditions. FAA and TAA levels in HM sampled at 6 weeks (

Indexed as

Infant HealthMothersAdultAmino AcidsAnthropometryFemaleHumansInfantLactationMaleMilk, HumanSex CharacteristicsAmino Acidsallergybreastfeedingfree amino acidsgrowthhuman milklactation

Identifiers

PMID34200908
PMCPMC8230437
OpenAlexW3171216709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.