Evidence map›Paper›PMID 34200901›Full record

ReviewMolecules (Basel, Switzerland)2021

From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides.

Pasqualina Liana Scognamiglio, Chiara Platella, Ettore Napolitano, Domenica Musumeci, Giovanni Nicola Roviello

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Pasqualina Liana ScognamiglioCenter for Advanced Biomaterial for Health Care (CABHC), Istituto Italiano di Tecnologia, I-80125 Naples, Italy.
Chiara PlatellaDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, Italy.ORCID 0000-0002-6997-1767
Ettore NapolitanoDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, Italy.
Domenica MusumeciDepartment of Chemical Sciences, University of Naples Federico II, via Cintia 21, I-80126 Naples, Italy.ORCID 0000-0001-7624-1933
Giovanni Nicola RovielloIstituto di Biostrutture e Bioimmagini IBB-CNR, via Tommaso De Amicis 95, I-80145 Naples, Italy.ORCID 0000-0002-6978-542X
Institute of Biostructure and Bioimaging · ITUniversity of Naples Federico II · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involved in the onset and progression of pathologies of high social impact. Nucleobase-bearing peptides (nucleopeptides) and pseudopeptides (PNAs) offer further interesting possibilities related to their nucleobase-decorated nature for diagnostic and therapeutic applications, thanks to their reported ability to target complementary DNA and RNA strands. In addition, these chimeric compounds are endowed with intriguing self-assembling properties, which are at the heart of their investigation as self-replicating materials in prebiotic chemistry, as well as their application as constituents of innovative drug delivery systems and, more generally, as novel nanomaterials to be employed in biomedicine. Herein we describe the properties of nucleopeptides, PNAs and related supramolecular systems, and summarize some of the most relevant applications of these systems.

Indexed as

DNANanostructuresPeptide Nucleic AcidsPeptidesRNADNAPeptide Nucleic AcidsPeptidesRNAbioactivitydiagnosticnanomaterialsnucleic acidsnucleobasesnucleopeptidespeptidesPNAsprebioticself-assemblysupramoleculartherapeutic

Identifiers

PMID34200901
PMCPMC8230524
OpenAlexW3167640391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.