Observational studyNutrients2021
Association of Trimethylamine N-Oxide (TMAO) with the Clinical Severity of Hidradenitis Suppurativa (Acne Inversa).
Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic review.Frontiers in immunology · 2026Pooled it
- Adherence to Hidradenitis Suppurativa Treatment.American journal of clinical dermatology · 2024Pooled it
- Article
- The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential.Gut microbes · 2025Review
- Anti-IL-17 and Anti-IL-23 Therapies Modulate Serum Biomarkers of Intestinal Dysbiosis and Oxidative Stress Linked to Cardiovascular Risk in Patients with Psoriasis.Life (Basel, Switzerland) · 2025Article
- Association Between Altered Gut Microbiota and Acne Vulgaris: A Comparative Study of Trimethylamine N-Oxide Levels in Patients and Healthy Controls.Dermatology practical & conceptual · 2025Article
- The Role of Microbiota in the Pathogenesis of Bullous Pemphigoid and Pemphigus Vulgaris: Evidence, Controversies, and Perspectives.International journal of molecular sciences · 2025Review
- Review
- Beyond the skin: endocrine, psychological and nutritional aspects in women with hidradenitis suppurativa.Journal of translational medicine · 2025Review
- Effects of the ketogenic diet on skin-potential benefits and risks.Frontiers in nutrition · 2025Review
- Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne?Journal of translational medicine · 2024Article
- Very low-calorie ketogenic diet (VLCKD) in the management of hidradenitis suppurativa (Acne Inversa): an effective and safe tool for improvement of the clinical severity of disease. Results of a pilot study.Journal of translational medicine · 2024Article
- Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Obesity-associated inflammation countered by a Mediterranean diet: the role of gut-derived metabolites.Frontiers in nutrition · 2024Review
- Bacterial Metabolites and Inflammatory Skin Diseases.Metabolites · 2023Review
- Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach.Journal of translational medicine · 2023Article
- Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases.International journal of molecular sciences · 2023Review
- Mediterranean Diet and Obesity-related Disorders: What is the Evidence?Current obesity reports · 2022Review
- The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment.American journal of clinical dermatology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this case-control, cross-sectional, observational study, we evaluated circulating trimethylamine n-oxide (TMAO) levels, a gut-derived metabolite associated with inflammation and cardiometabolic risk, in patients with hidradenitis suppurativa (HS), a highly disabling inflammatory skin disease associated with an elevated prevalence of comorbidities, especially cardiovascular and metabolic diseases. In this study, we enrolled 35 naive-treatment patients with HS and 35 controls, matched for sex, age, and body mass index (BMI). HS Sartorius score was 49.0 (33.0-75.0), while according to the Harley system 12 and 23 patients presented grade 1 and grade 2 severity, respectively. HS patients had a lower adherence to the Mediterranean diet (MD) (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.