Evidence map›Paper›PMID 34200496›Full record

ArticleInternational journal of molecular sciences2021

Plasma Proteomic Analysis in Morquio A Disease.

José V Álvarez, Susana B Bravo, María Pilar Chantada-Vázquez, Sofía Barbosa-Gouveia, Cristóbal Colón, Olalla López-Suarez, Shunji Tomatsu, Francisco J Otero-Espinar, María L Couce

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Natural History of Morquio A Syndrome.Journal of inherited metabolic disease · 2026
    Review
  3. Review
  4. Novel Phenotypical and Biochemical Findings in Mucolipidosis Type II.International journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Proteomics in Inherited Metabolic Disorders.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Bone Biomarkers in Mucopolysaccharidoses.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

José V ÁlvarezDepartment of Forensic Sciences, Pathology, Gynecology and Obstetrics, Pediatrics, Neonatology Service, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, CIBERER, MetabERN, 15706 Santiago de Compostela, Spain.ORCID 0000-0003-3735-1341
Susana B BravoProteomic Platform, Health Research Institute of Santiago de Compostela (IDIS), Hospital ClínicoUniversitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0001-7615-3079
María Pilar Chantada-VázquezProteomic Platform, Health Research Institute of Santiago de Compostela (IDIS), Hospital ClínicoUniversitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Sofía Barbosa-GouveiaHealth Research Institute of Santiago de Compostela (IDIS), CIBERER, MetabERN, 15706 Santiago de Compostela, Spain.
Cristóbal ColónDepartment of Forensic Sciences, Pathology, Gynecology and Obstetrics, Pediatrics, Neonatology Service, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, CIBERER, MetabERN, 15706 Santiago de Compostela, Spain.ORCID 0000-0002-9711-2812
Olalla López-SuarezDepartment of Forensic Sciences, Pathology, Gynecology and Obstetrics, Pediatrics, Neonatology Service, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, CIBERER, MetabERN, 15706 Santiago de Compostela, Spain.
Shunji TomatsuSkeletal Dysplasia Lab Nemours Biomedical Research Nemours/Alfred I, duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA.ORCID 0000-0002-0673-2160
Francisco J Otero-EspinarParaquasil Platform, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0001-9030-2253
María L CouceDepartment of Forensic Sciences, Pathology, Gynecology and Obstetrics, Pediatrics, Neonatology Service, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario de Santiago de Compostela, CIBERER, MetabERN, 15706 Santiago de Compostela, Spain.ORCID 0000-0003-4861-9905
Instituto de Investigación Sanitaria de Santiago · ESAlfred I. duPont Hospital for Children · USUniversidade de Santiago de Compostela · ES

Funding

Non-invasive functional assessment and pathogenesis of Morquio AR01HD102545 · NICHD · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI TOMATSU, SHUNJI · 2021 to 2025
$2.9M
NICHD NIH HHS R01 HD102545
6 · The paper itself

Abstract

Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal disease caused by mutations in the gene encoding the enzyme

Indexed as

BiomarkersCase-Control StudiesChondroitinsulfatasesEnzyme Replacement TherapyHumansMucopolysaccharidosis IVProteomeBiomarkersChondroitinsulfatasesProteomebiomarkersenzyme replacement therapylysosomal disordersproteomics

Identifiers

PMID34200496
PMCPMC8201332
OpenAlexW3172053221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.